Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteinases 2 and 9 expression and activity

Sani, Iman Karimi; Marashi, Hassan; Kalalinia, Fatemeh

doi:10.1016/j.tiv.2015.03.012

Cited by 61 publications

(45 citation statements)

References 44 publications

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“…We evaluated the inhibitory effects of solamargine on hepatocellular carcinoma cell migration and invasion. We showed that treatment with solamargine significantly decreased the invasion and migration ability of HepG2 cells in a concentration‐dependent manner (Sani et al ., ).…”

Section: Resultsmentioning

confidence: 97%

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Anticancer Properties of Solamargine: A Systematic Review

Kalalinia

Karimi-Sani

2017

Phytother. Res.

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Cancers are usually treated by anticancer agents that are toxic for both normal and cancer cells, so these drugs have major side effects and they are not suitable and enough effective for cancer prevention. Solamargine, a steroidal alkaloid glycoside found in Solanum species such as Solanum nigrum, displayed several therapeutic activities. We aim to review the use of solamargine in experimental cancer studies. Articles published in biology journals between 1975 and 2017 were retrieved from PubMed, Scopus, and Web of Science using relevant keywords. The scientific papers mainly focusing on solamargine with therapeutic efficacies against cancers were identified and tabulated. In addition, the reliability of experimental findings was determined under "Risk of Bias" criteria. The author manually reviewed 33 articles; 27 articles were found concerning the anti-cancer potential in cancer cells. Solamargine has been found to possess anticancer activities via its effect on a variety of biological pathways including cell survival pathways, tumor suppressor pathways, caspase activation pathway, mitochondrial pathways, death receptor pathways, protein kinase pathways, and signal pathways, which promote invasion/migration and multi drug resistance. Solamargine can be an anticancer agent candidate when complementary scientific evidences become available. Copyright © 2017 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 97%

“…). Overall, these evidences strongly indicated that solamargine can inhibit migration and invasion of HepG2 cells through downregulation of MMP‐2 and ‐9 expression and activity in vitro (Sani et al ., ).…”

Section: Resultsmentioning

confidence: 97%

Anticancer Properties of Solamargine: A Systematic Review

Kalalinia

Karimi-Sani

2017

Phytother. Res.

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“…15 9 | REGULATION OF MICRORNAS BY BIOACTIVE MOLECULES OF S. NIGRUM MicroRNAs (miRNAs) are small, noncoding RNA molecules involved in regulation of gene expression by specifically binding to messenger RNAs (mRNAs). This section deals with the bioactive constituents of S. nigrum that exert inhibitory effects on MMPs.…”

Section: Sonic Hedgehog Pathway Inhibitionmentioning

confidence: 99%

Emerging themes of regulation of oncogenic proteins by Solanum nigrum and its bioactive molecules in different cancers

Butt

Romero

Tahir

et al. 2018

J of Cellular Biochemistry

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Research over the decades has sequentially and systematically provided a near-complete resolution of multifaceted and therapeutically challenging nature of cancer. Drug discovery from plants has enjoyed a renaissance in the past few years. Natural products have provided many of the lead structures, which are currently being used as templates for the design and synthesis of novel compounds with biologically enhanced properties. With the maturity and diversification of technologies, there is a growing need to design high-throughput functional assays for the evaluation of the myriad of compounds being catalogued. This review sheds light on the tumor suppressive properties of Solanum nigrum and its bioactive ingredients. Several worthy of mention include uttroside B, solanine, solamargine, and physalins, which have been tested for efficacy in cancer cell lines and xenografted mice. We have summarized the most recent findings related to S. nigrum-mediated regulation of intracellular protein network in different cancers. α-Solanine, an active component of S. nigrum, is involved in the regulation of microRNA-21 (miRNA-21) (oncogenic) and miRNA-138 (tumor suppressor) in prostate cancer. However, this is the only available evidence that gives us a clue related to the tumor suppressive effects exerted by components of S. nigrum at a posttranscriptional level. More interestingly, S. nigrum and its components exerted inhibitory effects on different pathways including PI3K/AKT, JAK-STAT, VEGF/VEGFR, and matrix metalloproteinases in different cancers. We also provide an overview of new tools, methodologies, and approaches, which will allow researchers to extract as much information as possible out of the tremendous data sets currently being generated. The use of computational tools will be helpful in processing structurally complex natural products and also in prediction of their macromolecular targets.

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“…MMP-2 and MMP-9 contribute to the establishment of metastasis-prone sites at tumor-distant organs [67]. SM suppresses the invasive capacity of HepG2 cells by downregulation of MMP-2 and MMP-9 expressions and activities [68].…”

Section: Metastasismentioning

confidence: 99%

Solasodine, Solamargine and Mixtures of Solasodine Rhamnosides: Pathway to Expansive Clinical Anticancer Therapies

Cham¹

2017

IJCM

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Cancer remains a major cause of mortality worldwide. Progresses have been made in the understanding of the molecular basis of cancer, cancer detection, and cancer treatment. Important strides by treating early-stage cancers have resulted in improved outcomes. Despite these achievements, mortality of cancer patients is high and still there is no cure. Some oncologists remain optimistic that cytotoxic chemotherapy will significantly improve cancer survival. However, notwithstanding the use of new and expensive single and more recently, combination drugs, the improvement of the response rates remains very low. In the United States, cancer death rates decreased by a mere 1.4% to 1.8% from 2004 to 2013. Compared to other serious diseases, the improvement of the cancer patient has been disappointingly lagging, and by far, most patients with advanced cancer eventually die of their disease. The need for improved cancer therapies is self-evident. This communication gives an overview of the overwhelming resurgence of solasodine and its glycosides in cancer therapy.

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Solamargine inhibits migration and invasion of human hepatocellular carcinoma cells through down-regulation of matrix metalloproteinases 2 and 9 expression and activity

Cited by 61 publications

References 44 publications

Anticancer Properties of Solamargine: A Systematic Review

Anticancer Properties of Solamargine: A Systematic Review

Emerging themes of regulation of oncogenic proteins by Solanum nigrum and its bioactive molecules in different cancers

Solasodine, Solamargine and Mixtures of Solasodine Rhamnosides: Pathway to Expansive Clinical Anticancer Therapies

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