PGA-incorporated collagen: Toward a biodegradable composite scaffold for bone-tissue engineering

Toosi, Shirin; Naderi‐Meshkin, Hojjat; Kalalinia, Fatemeh; Peivandi, Mohammad Taghi; Hosseinkhani, Hossein; Bahrami, Ahmad Reza; Heirani‐Tabasi, Asieh; Mirahmadi, Mahdi; Behravan, Javad

doi:10.1002/jbm.a.35736

Cited by 61 publications

(48 citation statements)

References 37 publications

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“…investigated Raman spectrum of hydroxyapatite/gelatin composites prepared under pH 7, 8, 9, and 10 and found that a higher pH (9‐10) might lead to the dissolution of gelatin . However, no pH‐responsive modifications of Amide I, II, and III associated with the triple helical structure of collagen molecules were observed, revealing that the pH in the range of 7.9‑10.4 did not alter the second structure of collagen . Furthermore, the SDS‐PAGE patterns for the solutions at different pH were similar and displayed two α bands (110 kDa for α1 and α2) and one β band (250 kDa) (Figure S2), indicating that the collagen was not denatured with increasing pH values (7.9–10.4).…”

Section: Resultsmentioning

confidence: 99%

pH‐responsive variation of biomineralization via collagen self‐assembly and the simultaneous formation of apatite minerals

Shen

Yang

et al. 2019

J of Applied Polymer Sci

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Collagen self-assembly and simultaneous mineralization by incubating a mixture containing collagen, calcium, and phosphate ions under physiological conditions, is an effective method to prepare bone-like biomimetic materials. The formation of fibrils and minerals is related to pH of system. In the present work, we evaluated the effect of pH (7.9-10.4) on biomineralization process and synthesized composites. Turbidity kinetics and X-ray diffraction (XRD) measurements revealed that increasing pH delayed the crystallization process from nucleation phase to plateau phase because of promoting chelation of Ca 2+ with collagen. Typical peaks of phosphate in Fourier transform infrared spectroscopy coupling with characteristic peaks of hydroxyapatite (HAp) in XRD spectra illustrated the formation of HAp after biomineralization. Scanning electron microscopy measurements indicated that the increase of pH promoted the deposition of spherical minerals in fibrils. Especially, the minerals tended to form cluster-like structure at pH 10.4. The hyp content, Ca and P contents, and gel strength measurements suggested that higher pH promoted the formation of HAp with a Ca/P closed to 1.67 and the prolongation of crystallization gave the time for collagen self-assembly leading to the increase of gel strength at higher pH (9.4-10.4). These results might provide some new ideas for designing biomimetic materials.

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Section: Resultsmentioning

confidence: 99%

pH‐responsive variation of biomineralization via collagen self‐assembly and the simultaneous formation of apatite minerals

Shen

Yang

et al. 2019

J of Applied Polymer Sci

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“…Due to the limited availability of donors, only a fraction of individuals who could benefit from organ transplantations actually receive them. One possible avenue for remedying this situation is to artificially engineer human tissues [44][45][46][47][48][49][50][51]. One of the central themes of tissue engineering is to reproduce the body's architectural and geometric intricacies, including vital cell-cell interactions.…”

Section: Tissue Engineering Strategymentioning

confidence: 99%

Current progress in hepatic tissue regeneration by tissue engineering

et al. 2019

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Background: Liver, as a vital organ, is responsible for a wide range of biological functions to maintain homeostasis and any type of damages to hepatic tissue contributes to disease progression and death. Viral infection, trauma, carcinoma, alcohol misuse and inborn errors of metabolism are common causes of liver diseases are a severe known reason for leading to end-stage liver disease or liver failure. In either way, liver transplantation is the only treatment option which is, however, hampered by the increasing scarcity of organ donor. Over the past years, considerable efforts have been directed toward liver regeneration aiming at developing new approaches and methodologies to enhance the transplantation process. These approaches include producing decellularized scaffolds from the liver organ, 3D bio-printing system, and nano-based 3D scaffolds to simulate the native liver microenvironment. The application of small molecules and micro-RNAs and genetic manipulation in favor of hepatic differentiation of distinct stem cells could also be exploited. All of these strategies will help to facilitate the application of stem cells in human medicine. This article reviews the most recent strategies to generate a high amount of mature hepatocyte-like cells and updates current knowledge on liver regenerative medicine.

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“…It should be noted that the biopolymers of PGA and PCL, which are the carrier of drug and coated on the suture, have different degradation rate. The degradation rate of PGA is higher than that of PCL [16][17][18]. We can control the degradation rate of drug-carrier by adjusting the proportion of PGA and PCL.…”

Section: Introductionmentioning

confidence: 99%

Controllable Drug Release Behavior of Polylactic Acid (PLA) Surgical Suture Coating with Ciprofloxacin (CPFX)—Polycaprolactone (PCL)/Polyglycolide (PGA)

Liu

et al. 2020

Polymers

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Polylactic acid (PLA) surgical suture can be absorbed by human body. In order to avoid surgical site infections (SSIs), the drug is usually loaded on the PLA suture, and then the drug can release directly to the wound. Because the different types of wounds heal at different times, it is needed to control the drug release rate of PLA suture to consistent to the wound healing time. Two biopolymers, polyglycolide (PGA) and polycaprolactone (PCL), were selected as the carrier of ciprofloxacin (CPFX) drug, and then the CPFX-PCL/PGA was coated on the PLA suture. The degradation rate of drug-carrier can be controlled by adjusting the proportion of PCL/PGA, which can regulate the rate of CPFX drug release from PLA suture. The results show that the surface of PLA suture, coating with PCL/PGA, was very rough, which led to increased stitching resistance when we were suturing the wound. These materials, such as the PLA suture, the PCL/PGA carriers and the CPFX drug, were just physically mixed rather than chemically reacted, which was very useful for ensuring the original efficacy of CPFX drug. With the increasing of PCL in the carriers, both the breaking strength and elongation of these un-degraded sutures increased. During degradation, the breaking strength of all sutures gradually decreased, and the more PCL in the coating materials, the longer effective strength-time for the suture. With the increasing of PCL in the drug-carrier, the rate of drug releasing became lower. The drug release mechanism of CPFX-PCL/PGA was a synergistic effect of drug diffusion and PCL/PGA carrier dissolution.

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PGA-incorporated collagen: Toward a biodegradable composite scaffold for bone-tissue engineering

Cited by 61 publications

References 37 publications

pH‐responsive variation of biomineralization via collagen self‐assembly and the simultaneous formation of apatite minerals

pH‐responsive variation of biomineralization via collagen self‐assembly and the simultaneous formation of apatite minerals

Current progress in hepatic tissue regeneration by tissue engineering

Controllable Drug Release Behavior of Polylactic Acid (PLA) Surgical Suture Coating with Ciprofloxacin (CPFX)—Polycaprolactone (PCL)/Polyglycolide (PGA)

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