Diabetic foot ulcers (DFU) is a lesion of all layers of skin, necrosis or gangrene that occurs in the soles of the feet in diabetes mellitus (DM) patients, caused by: (1) causative factor (peripheral neuropathy, high foot plantar pressure and trauma); (2) contributive factors (atherosclerosis and diabetes). The treatments of diabetic ulcers consist of determining and repairing the underlying cause of ulcer, good wound care and prevention of ulcer recurrence. The cause of diabetic ulcers can be determined by deep anamnesis and physical examination. DFU therapy includes necrotomy/debridement, reducing the load/pressure on the offensive area, manage the infection by diagnosing the type of bacteria, providing adequate antibiotics and ulcer treatment using wound dressing clean and moist.

Diabetic foot ulcer (DFU) is among the many complications of diabetes and it takes a very long period of time to heal. It can lead to the amputation of the lower limb, thereby resulting to death or in most cases, a bad quality of life. The aim and objective of this study is to assess the effect of bitter melon leaves extracts on serum TNF-α levels and improvement of diabetic foot ulcers. The study technique used here is the randomized, double-blinded, placebo-controlled trial. Thirty patients suffering from DFU participated in the trial and according to PEDIS scores were divided into two groups, of which 15 patients were in the treatment group and administered with bitter melon leaves extract at a dose of 6 g/day and the remaining 15 patients were in the control group and were given placebo. This intervention was done for 4 weeks and the examination of serum TNF-α levels was carried out at baseline and at the end of treatment. The readings of the healing process for diabetic foot ulcers with PEDIS scores were also taken at baseline, weeks 2, 3 and 4. Data were analyzed using the paired t-test and the independent t test. After 4 weeks of treatment, there was a decrease in baseline serum TNF-α levels in the treatment and control groups (29.5 ± 8.6 pg/ml, P = 0.0001 and 202.5 ± 610.2 pg/ml, P = 0.001). There was no effect on serum TNF-α levels (P = 0.28). There was a decrease in PEDIS degrees from baseline, week 2, 3 and 4 in the treatment and control groups (2.7±0.5; 2.7±0.5; 2.7±0.6; 1.9±0.6 and 2.6±0.5; 2.6±0.5; 2.5±0.6; 2.2±0.8). However there was no effect on diabetic foot ulcer improvement both groups in week 2 (P = 0.46), week 3 (P = 0.57) and week 4 (P = 0.29). Bitter melon leaves extracts is proven to have no effect on the serum TNF-α levels and improvement of diabetic foot ulcers.

Masalah kesehatan yang terjadi pada lansia umumnya adalah penurunan fungsi organ yang memicu terjadinya berbagai penyakit degeneratif termasuk hipertensi. Penyakit degeneratif pada lansia jika tidak ditangani dengan baik maka menurunkan kualitas hidup lansia. Hipertensi merupakan suatu gejala penyakit degeneratif kardiovaskuler yang paling banyak di alami oleh lansia dan belum dapat diketahui dengan pasti penyebabnya. Penatalaksanaan hipertensi pada lansia selain dengan farmakologi dapat pula dilakukan dengan non farmakologi seperti senam hipertensi. Penelitian ini bertujuan untuk mengetahui pengaruh senam hipertensi lansia terhadap penurunan tekanan darah lansia dengan hipertensi di Panti Wredha Darma Bhakti Kelurahan Pajang Surakarta. Penelitian ini adalah penelitian kuantitatif dengan rancangan preexperiment design One Group Pre test-post test. Pengumpulan data menggunakan Sphygmomanometer air raksa, sedangkan analisis data menggunakan uji Wilcoxon Signed Rank Test. Hasil dari penelitian ini adalah tekanan darah sebelum pemberian intervensi sebagian besar adalah prehypertension (39%), tekanan darah setelah pemberian intervensi senam hipertensi sebagian besar adalah normal (56%), danterdapat pengaruh senam hipertensi terhadap tekanan darah lansia di Panti Wredha Dharma Bhakti Pajang Surakarta (p-value = 0,001).

Masalah kesehatan yang terjadi pada lansia umumnya adalah penurunan fungsi organ yang memicu terjadinya berbagai penyakit degeneratif termasuk hipertensi. Penyakit degeneratif pada lansia jika tidak ditangani dengan baik maka menurunkan kualitas hidup lansia. Hipertensi merupakan suatu gejala penyakit degeneratif kardiovaskuler yang paling banyak di alami oleh lansia dan belum dapat diketahui dengan pasti penyebabnya. Penatalaksanaan hipertensi pada lansia selain dengan farmakologi dapat pula dilakukan dengan non farmakologi seperti senam hipertensi. Penelitian ini bertujuan untuk mengetahui pengaruh senam hipertensi lansia terhadap penurunan tekanan darah lansia dengan hipertensi di Panti Wredha Darma Bhakti Kelurahan Pajang Surakarta. Penelitian ini adalah penelitian kuantitatif dengan rancangan preexperiment design One Group Pre test-post test. Pengumpulan data menggunakan Sphygmomanometer air raksa, sedangkan analisis data menggunakan uji Wilcoxon Signed Rank Test. Hasil dari penelitian ini adalah tekanan darah sebelum pemberian intervensi sebagian besar adalah prehypertension (39%), tekanan darah setelah pemberian intervensi senam hipertensi sebagian besar adalah normal (56%), danterdapat pengaruh senam hipertensi terhadap tekanan darah lansia di Panti Wredha Dharma Bhakti Pajang Surakarta (p-value = 0,001).

Objective: This study aims to prove the effect of supplementation of bitter melon leaves extract on glycemic status in diabetic foot ulcer (DFU). Materials and Methods: This study used a randomized, double-blinded, and placebo-controlled trial. Thirty DFU patients based on PEDIS 1-8 scores who met the criteria were divided into 2 groups consisting of 15 patients as a treatment group with the administration of bitter melon leaves extract at a dose of 6 g/day and 15 patients as a control group of with placebo. This intervention was conducted in 4 weeks. Glycemic status was measured by the value of glycated albumin and examined at baseline and at the end of treatment. Data were analyzed using paired t-test and independent t-test. Results: After 4 weeks of treatment, there was an increase in the baseline value of glycated albumin in the treatment group from 24.5 ± 11.7% to 25.8 ± 12.7% or an increase of 1.3 ± 6.3% and a decrease in the control group from 27.5 ± 13.1% to 25.8 ± 8.5% or a decrease of 1.7 ± 12.4%. The results of the analysis of the effect of supplementation of bitter melon leaves extract on the value of glycated albumin were not significant (p = 0.99). Conclusion: The supplementation of bitter melon leaf extract with a dose of 6 g / day did not significantly affect the value of glycated albumin. Bangladesh Journal of Medical Science Vol.20(2) 2021 p.281-287

BACKGROUND: Diabetes mellitus is a serious disease that affects more than 340 million people and causes approximately 20% of diabetic ulcer cases worldwide. Wound healing is a complex and dynamic process in restoring cellular structures and tissue layers. It consists of four continuous overlapping phases that are precisely programmed AIM: This study aims to examine the adjuvant administration of bitter melon leaf extract to increase the healing of diabetic foot ulcers (DFU). METHODS: This study used a randomized, double-blind, and placebo-controlled trial. A total of 30 DFU patients with a perfusion, extent, depth, infection, and sensation (PEDIS) score of 1–8 who met the criteria were divided into two groups, namely, the treatment group with adjuvant administration of bitter melon leaf extract at a dose of 6 g/day as many as 15 patients and the control group 15 patients with placebo. This intervention was carried out for 4 weeks. DFU cure was measured by PEDIS scores at baseline, weeks 2, 3, and the end of week 4. Data were analyzed using paired t-test and independent t-test. RESULTS: After 4 weeks of treatment, the PEDIS score in the treatment group decreased at week 2 (0.9 ± 1.8), but not significant (p = 0.19), decreased at week 3 (1.9 ± 1.9) and significant (p = 0.01), decreased in week IV (2.3 ± 2.1) and significantly (p = 0.001). The control group experienced a decrease in week 2 (0.3 ± 2.3), but not significant (p = 0.71), decreased in week 3 (1.2 ± 2.5), but not significant (p = 0.18), decreased in week 4 (1.9 ± 2.7) and significantly (p = 0.03), and there was an effect of adjuvant administration of bitter melon leaf extract on the cure of DFU (p = 0.004). CONCLUSION: Adjuvant administration of bitter melon leaf extract has been shown to increase the healing of DFU.

One complication of Type 2 Diabetes Mellitus that affects the peripheral nervous system is Peripheral Artery Disease (PAD). PAD can be detected by checking the Ankle Brachial Index (ABI). PAD diagnostic tests with greater ABI accuracy are likely to reflect changes in a person's quality of life related to the conditions experienced. The purpose of this study was to determine the relationship between ABI values with the quality of life of people with DM. This type of research is analytic (survey) using a cross sectional approach. The sample used in this study were 44 type 2 DM patients in the Surakarta City branch of Persadia. The sampling technique used was purposive sampling. The instrument used to record data using a questionnaire, sphygmomanometer and stethoscope. Based on the analysis using the Chi-Square test, the value of p = 0.010 (p

The purpose of this study was to assess fasting blood glucose (GDP) levels and correlate with quality of life in patients with diabetic foot ulcers (UKD). The design of this study uses clinical-based cross-sectional research. The results of this study found that most of the GDP levels in the category of hyperglycemia were 31 patients (62%) and a small proportion of hypoglycemia were 5 patients (10%). Quality of life was mostly good as many as 43 patients (86%) and a small proportion of poor as many as 7 patients (14%). Most of the GDP levels in the category of hyperglycemia with good quality of life were 17 patients (34%) and a small percentage of GDP with normoglycemia category with a good quality of life were 1 patient (2%). Statistical test results showed that the level of GDP was significantly related to quality of life in UKD patients (p = 0.04). Conclusions, GDP levels are significantly related to quality of life in UKD patients.   Keywords: Diabetes mellitus, GDP levels, Quality of life, Diabetic foot ulcers