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Analgesia or hyperalgesia has been reported to occur in animals under different stress conditions. this study examined the effect of acute restraint stress on nociception in rats. Acute restraint stress produced a time-dependant decrease in pain threshold; this hyperalgesia was not affected by prior administration of adrenergic blockers suggesting the non-involvement of adrenergic mechanisms. The hyperalgesia may however result from a change in the affective state of the animal and not from a change in sensory processing of noxious stimulus.

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The responses to inflammatory pain were assessed in a rat model of post surgical pain using the formalin test. There were significantly reduced nociceptive responses in the second phase of the formalin test in both ipsilateral and contralateral limbs. The results either reflect reduced activity in mechanically insensitive afferents, A and C fibers that mediate the second phase response, or a diffuse noxious inhibitory controls mechanism (DNIC).

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