Immunomodulatory Effect of Warm Water Swim-stress in Adult Female Sprague Dawley Rats

Effect of Acute Warm Water Swim Stress on Antioxidant Levels in Swiss Albino Rats

“…Alpha-Tocopherol has a peripheral anti-inflammatory effect and this could be related to inhibition of scavenging of free radicals developed due to stress. Vitamin E increases the level of prostaglandins which was decreased during stress which may enhance the exploratory and loco motor activity 8 . Apha-Tocopherol inhibits the activity of nitric oxide .This action was done by inhibiting the gene responsible for activation of the transcription factor NF -κ KB by nitric oxide 17 .…”

“…The experimental group rats were exposed to heat water swim stress at 40ºC for duration of 15min between 09.00AM to11.00AM for one day. Blood samples are collected from jugular vein after heat water swim stress for antioxidant estimation 8 . The Lipid peroxidation (LPO), enzymatic antioxidant estimation like Superoxide dismutase (SOD), Glutathione peroxidase (GPx), and non-enzymatic antioxidants like Vitamin C, Vitamin E are estimated.…”

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“…The rats were divided into 2 groups, (a) Control group, (6), and (b) acute heat stress group (6). The control group was kept in a home cage without any disturbance, whereas rats in the stress group were exposed to biological oxygen demand incubator at 38ºC for the duration of four hours for a single day between 08.00AM to12.00AM 10 . After heat stress, blood samples were collected from the jugular vein for estimating the antioxidant status of animals.…”