Chronic stress induced duration dependent alterations in immune system and their reversibility in rats

Sarjan, Halugudde Nagaraja; Yajurvedi, H. N.

doi:10.1016/j.imlet.2018.02.008

Cited by 13 publications

(10 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animals exposed to subacute noise stress showed more enhanced avidity index in Candida phagocytosis. The response of neutrophils may be maintained by the sympathetic nervous system (Sarjan and Yajurvedi, 2018). Neutrophils are enhanced with alpha and beta adrenergic receptors.…”

Section: Discussionmentioning

confidence: 99%

Antistressor effect of Costus speciosus on noise induced immunological changes in rats

Ilango

Saikumar

Sembulingam³

et al. 2020

ijrps

View full text Add to dashboard Cite

Costus speciosus is being widely used in Indian folk medicine for treating various disorders. Environmental noise pollution is supposed to be an important factor for many health problems and it causes immune abnormalities. In the present study immune-regulating potential of Costus speciosus extract was evaluated during acute and subacute noise stress conditions. Adult Wistar albino rats were exposed to acute noise stress and subacute noise stress and then the effect of ethanolic Costus speciosus rhizome extract on immunological parameters such as phagocytic index, avidity index, neutrophil adherence test and total leucocyte count were studied. Neutrophil adherence and total leukocyte counts were found decreased and the percentage of avidity and phagocytic index were significantly increased in the stressed group of rats. The result of statistical analysis showed that, the pre-treatment with Costus speciosus extract significantly altered favourably the levels of immunological parameters. Ethanolic extract of Costus speciosus rhizome have the potential to prevent noise stress induced changes in rodent immune system and has a strong immunomodulatory prospective applicable to clinical practices.

show abstract

Section: Discussionmentioning

confidence: 99%

Antistressor effect of Costus speciosus on noise induced immunological changes in rats

Ilango

Saikumar

Sembulingam³

et al. 2020

ijrps

View full text Add to dashboard Cite

show abstract

“…Corticosterone, which is closely related to chronic stress responses, increases the number of neutrophils in the bone marrow (Sarjan and Yajurvedi, 2018). Catecholamines, which are chronic stress response factors, promote the proliferation and recruitment of hematopoietic stem cells in the bone marrow (Hanns et al, 2019).…”

Section: Ilβ and Il-mentioning

confidence: 99%

Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure

Miyata

Ishino

Shimizu

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

Major depressive disorder (MDD) is a multifactorial disease affected by several environmental factors. Although several potential onset hypotheses have been identified, the molecular mechanisms underlying the pathogenesis of this disorder remain unclear. Several recent studies have suggested that among many environmental factors, inflammation and immune abnormalities in the brain or the peripheral tissues are associated with the onset of MDDs. Furthermore, several stress-related hypotheses have been proposed to explain the onset of MDDs. Thus, inflammation or immune abnormalities can be considered stress responses that occur within the brain or other tissues and are regarded as one of the mechanisms underlying the stress hypothesis of MDDs. Therefore, we introduce several current advances in inflammation studies in the brain that might be related to the pathophysiology of MDD due to stress exposure in this review.

show abstract

“… Stress and immune system: Because stress neuropeptides and hormones are widely produced in immune cells, much study has focused on the impact of stress on the immune system (IS). Inflammatory biomarkers and cytokines can be elevated in the bloodstream when people are under stress, which can lead to infections and tissue damage (27) . A feedback signal from stress-stimulated immune cells, known as cytokines, is sent to the nervous system, which in turn influences brain activity and the release of stress hormones, which in turn alter behaviour and cognitive abilities.…”

Section:  Cardiovascular Systemmentioning

confidence: 99%

Important Notes and Influences of Stress: Review Article

Alla¹,

Hussein²,

Sehlo³

et al. 2022

The Egyptian Journal of Hospital Medicine

View full text Add to dashboard Cite

Background: A stress response is triggered by any physical or psychological stimulation that disturbs balance. Stressors are the stimuli, and the stress response is the physiological and behavioural changes that occur as a result of being exposed to them. Body systems such as the sympathetic-adreno-medulla (SAM), hypothalamus-pituitary-adrenal (HPA), and immunological systems are activated in reaction to stressful situations. It's an adaptability process that helps the body deal with challenges provided by an internal or external stressor. It has maladaptive and detrimental effects on the body's physiology when a stressor is too severe, frequent, or long-lasting (chronic stress). For example, persistent stress can create maladaptive reactions such as depression, anxiety, cognitive impairment, and heart disease. Objective: Aim of the review article to give an overview about stress and its influences on life. Methods: PubMed, Google scholar and Science direct were searched using the following keywords: Stress, Internal or external stressor, Chronic stress, Depression and Anxiety. The authors also screened references from the relevant literature, including all the identified studies and reviews, only the most recent or complete study was included between January 2001 and September 2021. Documents in a language apart from English have been excluded as sources for interpretation was not found. Papers apart from main scientific studies had been excluded: documents unavailable as total written text, conversation, conference abstract papers and dissertations. Conclusion: Stress can cause headaches, high blood pressure, heart disease, diabetes, skin diseases, asthma, arthritis, depression, and anxiety, among other conditions.

show abstract

Chronic stress induced duration dependent alterations in immune system and their reversibility in rats

Cited by 13 publications

References 75 publications

Antistressor effect of Costus speciosus on noise induced immunological changes in rats

Antistressor effect of Costus speciosus on noise induced immunological changes in rats

Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure

Important Notes and Influences of Stress: Review Article

Contact Info

Product

Resources

About