Water Balance and Serum Levels of Some Electrolytes in Oral Contraceptive-Treated Female Wistar Rats

Akhigbe, R.E.; Ige, S.F.; Afolabi, A.O.; Oyeyipo, Peter I.; Ajao, F.O.; Ajayi, Ayodeji Folorunsho

doi:10.3923/jms.2008.591.594

Cited by 12 publications

(9 citation statements)

References 8 publications

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“…They were acclimatized for two weeks before the experimental period. [1112] Procedures involving the animals and their care were performed in accordance with the guidelines of the Animal Ethics Committee of the institution and guidelines of the National Institutes of Health (NIH) for the care and use of animals.…”

Section: Methodsmentioning

confidence: 99%

Oxidative status in rat kidney exposed to petroleum hydrocarbons

2013

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Objective:The study investigates the possible role of oxidative stress on renal tissues in association with petroleum hydrocarbon-induced nephrotoxicity.Materials and Methods:Rats of comparable weights were randomly distributed into 10 groups: Control and groups exposed to kerosene, petrol, and diesel via inhalation, contamination by food, and contamination by water. The exposure lasted for eight weeks.Results:Exposure to petroleum hydrocarbon led to significant rise in serum urea and creatinine, and renal tissue malondialdehyde. It also caused significant reduction in urinary urea and creatinine, and reduced glutathione, superoxide dismutase, and catalase activities of renal tissue homogenate. However, serum and urine concentrations of albumin and total protein were comparable in all groups.Conclusion:Results from this study shows that exposure to petroleum hydrocarbon led to renal dysfunction via oxidative stress, increasing lipid peroxidation and reducing the antioxidant defense mechanism.

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Section: Methodsmentioning

confidence: 99%

Oxidative status in rat kidney exposed to petroleum hydrocarbons

2013

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“…[18] Serum bicarbonate, urea, and creatinine were determined using the standard assay kit following back titration, diacetyl monoxime, and alkaline picrate methods, respectively.…”

Section: Methodsmentioning

confidence: 99%

Changes in Serum Electrolytes, Urea, and Creatinine in Aloe Vera-treated Rats

Saka¹,

Akhigbe²,

Popoola³

et al. 2012

Journal of Young Pharmacists

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This study was carried out to investigate the effect of Aloe vera extract (AvE) on serum electrolytes, urea, and creatinine as indices of renal function in Sprague-Dawley rats. Twelve male Sprague-Dawley rats weighing between 80 and 130 g were used. Rats were divided into two groups: The control and the test groups (n=6). The test group received 1 ml of AvE daily for 28 days. Both the groups fed on standard rat chow and water ad libitum. The results showed a decrease in serum levels of sodium, and potassium, but an increase in the serum levels of bicarbonate, urea, and creatinine in the test group. The changes seen were, however, statistically insignificant, except for the serum levels of sodium and creatinine (P<0.05). It is thus concluded that AvE impairs renal handling of electrolytes with consequent hyponatremia and hypercreatinemia. However, this might be of therapeutic value in conditions associated with hypernatremia.

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“…The fact that OC therapy reduces water consumption as reported by other researchers is a strong enough and reliable reason to hypothesize that it is the desired signal required to induce ADH secretion orchestrated by cellular dehydration for volume expansion, thus the dilution of the osmolarity. 14,[21][22][23][24] Although, the combine water retention together with secondary solute loss may result in reduction in serum sodium. 25 Hyponatremia is mediated initially by ADH-induced water retention that results in volume expansion causing dilution.…”

Section: Discussionmentioning

confidence: 99%