Acute restraint stress induces hyperalgesia via non-adrenergic mechanisms in rats

Oyadeyi, AS; Ajao, F.O.; Ibironke, G. F.; Afolabi, AO

doi:10.4314/ajbr.v8i2.35772

Cited by 4 publications

(8 citation statements)

References 12 publications

(3 reference statements)

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“…The authors interpret their findings as suggesting a role for sympathetic postganglionic nerves in enhancing pain sensation, possibly via a peripheral α1-adrenoceptor mediated mechanism. It is, however, worthwhile noting that these findings are at variance with previous reports suggesting no involvement of the adrenergic system in SIH based on a rat model of acute restraint stress (Oyadeyi et al, 2005). While these discrepancies warrant further investigation on the role of the adrenergic system in SIH, a key consideration in the interpretation of these data is the choice of the experimental paradigms employed to examine/model SIH.…”

Section: The Sympathetic Adrenomedullary and Peripheral Nervous Systemscontrasting

confidence: 68%

Stress-induced hyperalgesia

Jennings

Okine

Roche

et al. 2014

Progress in Neurobiology

221

179

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The importance of the modulation of pain by emotion is now widely recognised. In particular, stress and anxiety, depending on their nature, duration and intensity, can exert potent, but complex, modulatory influences typified by either a reduction or exacerbation of the pain state. Exposure to either acute or chronic stress can increase pain responding under experimental conditions and exacerbate clinical pain disorders. There is evidence that exposure to chronic or repeated stress can produce maladaptive neurobiological changes in pathways associated with pain processing, resulting in stress-induced hyperalgesia (SIH). Preclinical studies of SIH are essential for our understanding of the mechanisms underpinning stress-related pain syndromes and for the identification of neural pathways and substrates, and the development of novel therapeutic agents for their clinical management. In this review, we describe clinical and pre-clinical models used to study SIH and discuss the neural substrates, neurotransmitters and neuromodulatory systems involved in this phenomenon.

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Section: The Sympathetic Adrenomedullary and Peripheral Nervous Systemscontrasting

confidence: 68%

Stress-induced hyperalgesia

Jennings

Okine

Roche

et al. 2014

Progress in Neurobiology

221

179

View full text Add to dashboard Cite

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“…Group I (control) received distilled water (10 mL/kg) while groups II and III received acetaminophen (the reference drug, 100 mg/kg ip) and EEHE (1000 mg/kg po), 11 respectively. Groups IV–VII were pretreated with cimetidine (50 mg/kg ip), 22 naloxone (5 mg/kg ip), 23 propranolol (0.15 mg/kg ip), 24 and prazosin (0.15 mg/kg ip), 25 respectively, 20 minutes before EEHE (1000 mg/kg po) treatment. The tail immersion test was performed 1 hour after the final treatment.…”

Section: Methodsmentioning

confidence: 99%

Pharmacological mechanisms involved in the analgesia induced by ethanol extract of <em>Hybanthus enneaspermus</em> leaves

Afolabi¹,

Alagbonsi²,

Aliyu³

2017

JPR

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BackgroundHybanthus enneaspermus (HE) leaves are being used traditionally to relieve pain, and scientific studies have demonstrated their analgesic potential. This study attempted to elucidate the pharmacological mechanism(s) involved in the analgesic action of ethanol extract of H. enneaspermus leaves (EEHE).Materials and methodsForty-two male Wistar rats were separately randomized into seven groups (n=6 rats in each group) for tail immersion and formalin tests. Group I (control) received distilled water (10 mL/kg) while groups II and III received acetaminophen (the reference drug, 100 mg/kg ip) and EEHE (1000 mg/kg po), respectively. Groups IV–VII were pretreated with cimetidine (50 mg/kg ip), naloxone (5 mg/kg ip), propranolol (0.15 mg/kg ip), and prazosin (0.15 mg/kg ip), respectively, 1 hour before EEHE (1000 mg/kg po) treatment.ResultsThe EEHE-induced increase in tail-flick latency was reduced by blockade of histamine and adrenergic receptors but prevented by blockade of opiate receptor in the tail-flick test. However, the EEHE-induced decrease in paw licking time was prevented only by blockade of opiate receptor but unaffected by histamine and adrenergic receptors blockers.ConclusionThese findings suggest that the analgesic effect of EEHE in different pain types may involve different neural mechanisms and that the opioidergic pathway contributes more to EEHE-induced analgesia than the other pathways.

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“…Finally, inhibition of the catechol-O-methyltransferase (COMT) enzyme, which prevents the degradation of catecholamines, has been found to increase pain sensitivity through activation of β-ARs [ 71 ]. Although some contradictory findings exist [ 72 ], accumulating evidence suggests that sympathetic and adrenergic activity may be involved in stress intolerance (see Figure 1 ).…”

Section: Sympathetic and Adrenergic Activity Have A Role In Stress In...mentioning

confidence: 99%

The Biology of Stress Intolerance in Patients with Chronic Pain—State of the Art and Future Directions

Wyns

Hendrix

Lahousse

et al. 2023

JCM

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Stress has been consistently linked to negative impacts on physical and mental health. More specifically, patients with chronic pain experience stress intolerance, which is an exacerbation or occurrence of symptoms in response to any type of stress. The pathophysiological mechanisms underlying this phenomenon remain unsolved. In this state-of-the-art paper, we summarised the role of the autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis, the two major stress response systems in stress intolerance. We provided insights into such mechanisms based on evidence from clinical studies in both patients with chronic pain, showing dysregulated stress systems, and healthy controls supported by preclinical studies, highlighting the link between these systems and symptoms of stress intolerance. Furthermore, we explored the possible regulating role for (epi)genetic mechanisms influencing the ANS and HPA axis. The link between stress and chronic pain has become an important area of research as it has the potential to inform the development of interventions to improve the quality of life for individuals living with chronic pain. As stress has become a prevalent concern in modern society, understanding the connection between stress, HPA axis, ANS, and chronic health conditions such as chronic pain is crucial to improve public health and well-being.

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Acute restraint stress induces hyperalgesia via non-adrenergic mechanisms in rats

Cited by 4 publications

References 12 publications

Stress-induced hyperalgesia

Stress-induced hyperalgesia

Pharmacological mechanisms involved in the analgesia induced by ethanol extract of <em>Hybanthus enneaspermus</em> leaves

The Biology of Stress Intolerance in Patients with Chronic Pain—State of the Art and Future Directions

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