Hemorheological Effects of Long-Term Administration of Combined Oral Contraceptive in Rats

Akhigbe, R.E.; Azeez, M.O.; Ige, Serah Funke; Oyeyipo, Ibukun P.; Ajao, F.O.; Soladoye, Ayodele O.

doi:10.3923/ijp.2008.403.406

Cited by 14 publications

(12 citation statements)

References 17 publications

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“…The results recorded for this study also indicated that exposure to nitrocellulose thinner have adverse effect on the haematological indices, hence haematotoxicity, in rats. The haematotoxicity observed to be associated with oral exposure to nitrocellulose in this study agrees with our earlier reports on nitrocellulose thinner and gasoline [8,19,36], and that of other workers on such chemical agents as phenylhrazine, cadmium chloride, crude oil, some contraceptives, and pyrethroid insecticide [23,[37][38][39][40]. Typically, it has been reported that sub chronic intoxication of rats with 10 mg of phenylhydrazine per kg body weight per day for 8 days resulted in a marked haemolytic anaemia characterized by decreased red blood cell counts, haemoglobin and packed cell volume [22].…”

Section: Discussionsupporting

confidence: 91%

Withdrawal from Exposure Reverses Hematotoxicity and Hepatotoxicity Caused by Oral Exposure to Nitrocellulose Thinner in Male Rats

Ufot¹

2014

J Clinic Toxicol

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Nitrocellulose thinner (nct) is one of the commonly used industrial chemical solvents. Individuals involved in furniture, paint, automobile manufacture and repairs occupations, and those living around these workplace environments are at the risk of exposure to nct's constituents ubiquitously released into the environment. Oral exposure to this solvent has been reported to cause haematotoxicity and hepatotoxicity in rat model. This study assessed the impact of withdrawal from exposure, on nct induced-haematotoxicity and hepatotoxicity in male albino Wistar rats. Four groups, of twelve male rats each, were orally exposed to graded concentrations of nct for 28 days. After the 28 th day of exposure, six rats in each group were sacrificed and blood samples collected for nct inducedhaematotoxicity and hepatotoxicity analyses. The remaining six rats in each group were withdrawn from exposure for the next 28 days, after which they were sacrificed, blood samples collected and analyzed for any possible recovery effect from exposure-induced haematotoxicity and hepatotoxicity. The results confirmed that exposure of male rats to nct for 28 days caused a significant (P<0.05) concentration-dependent increase in haematotoxic and hepatotoxic indices, compared to the control. However, 28 days withdrawal from exposure produced a significant (P<0.05) reduction in the recorded haematotoxic and hepatotoxic indices, compared to the nct exposed groups. The results obtained for rats withdrawn from exposure were within the same range as those obtained for the control group, indicating that withdrawal from exposure may reverse the haematotoxic and hepatotoxic effects associated with exposure to nct in male rats.

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Section: Discussionsupporting

confidence: 91%

Withdrawal from Exposure Reverses Hematotoxicity and Hepatotoxicity Caused by Oral Exposure to Nitrocellulose Thinner in Male Rats

Ufot¹

2014

J Clinic Toxicol

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“…In addition to the effects of dilution on the drug-CD complex, competitive protein binding may also contribute to drug-CD dissociation. On the basis of published pharmacokinetic parameters (plasma clearance and volume of distribution) for SBE 7 -b-CD, 14 the maximum plasma SBE 7 -b-CD concentration in the present study was expected to be 0.8 mM, which is comparable to the plasma albumin concentration in the rat 15,16 However, chlorpromazine has been reported to have a high affinity for rat serum proteins, and the reported association constant for that interaction (1.09 Â 10 6 M À1 ) 17 is greater than 10-fold higher than the affinity of chlorpromazine for SBE 7 -b-CD. It is therefore likely that competitive plasma protein binding will contribute to rapid dissociation of the chlorpromazine-CD complex upon entering into the systemic circulation.…”

Section: Discussionmentioning

confidence: 75%

“…A predose sample of arterial blood was collected from each rat and subsequently during the 10 min infusion (5 and 10 min) and postdose (15,30,70,160,310, 610, 970, 1450 and 1810 min). Blood (120 mL) was collected directly into borosilicate vials (maintained at 48C) containing heparin, Complete 1 (a proprietary protease inhibitor cocktail), potassium fluoride, and EDTA to minimise potential for ex vivo metabolism in blood/plasma samples.…”

Section: Dosing and Sample Collectionmentioning

confidence: 99%

Impact of Chlorpromazine Self-Association on Its Apparent Binding Constants With Cyclodextrins: Effect of SBE7-β-CD on the Disposition of Chlorpromazine in the Rat

McIntosh

Leong

Katneni

et al. 2010

Journal of Pharmaceutical Sciences

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“…[15] Urine and serum levels of total protein and albumin were determined using standard assay kits. [16]…”

Section: Methodsmentioning

confidence: 99%

Oxidative status in rat kidney exposed to petroleum hydrocarbons

2013

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Objective:The study investigates the possible role of oxidative stress on renal tissues in association with petroleum hydrocarbon-induced nephrotoxicity.Materials and Methods:Rats of comparable weights were randomly distributed into 10 groups: Control and groups exposed to kerosene, petrol, and diesel via inhalation, contamination by food, and contamination by water. The exposure lasted for eight weeks.Results:Exposure to petroleum hydrocarbon led to significant rise in serum urea and creatinine, and renal tissue malondialdehyde. It also caused significant reduction in urinary urea and creatinine, and reduced glutathione, superoxide dismutase, and catalase activities of renal tissue homogenate. However, serum and urine concentrations of albumin and total protein were comparable in all groups.Conclusion:Results from this study shows that exposure to petroleum hydrocarbon led to renal dysfunction via oxidative stress, increasing lipid peroxidation and reducing the antioxidant defense mechanism.

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Hemorheological Effects of Long-Term Administration of Combined Oral Contraceptive in Rats

Cited by 14 publications

References 17 publications

Withdrawal from Exposure Reverses Hematotoxicity and Hepatotoxicity Caused by Oral Exposure to Nitrocellulose Thinner in Male Rats

Withdrawal from Exposure Reverses Hematotoxicity and Hepatotoxicity Caused by Oral Exposure to Nitrocellulose Thinner in Male Rats

Impact of Chlorpromazine Self-Association on Its Apparent Binding Constants With Cyclodextrins: Effect of SBE7-β-CD on the Disposition of Chlorpromazine in the Rat

Oxidative status in rat kidney exposed to petroleum hydrocarbons

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