in coronary occlusion and suggested the possibility that the disturbance in the cardiac mechanism may be due to myocardial anoxemia. In man deLavergne and his associates19 noted a transitory Stokes-Adams syndrome with brachycardia eight days after the injection of antistreptococcus serum for erysipelas, at which time serum sickness developed. Also, Harkavy20 observed certain cardiac arrythmias and angina pectoris in 3 patients when offended by certain allergens. The relation of the changes in the electrocardiograms to the anaphylactic shock in our case is conjectured. Nevertheless, there were abnormally broad P waves and flat Ts shortly after the shock which returned to normal later. SUMMARY A man aged 22 had severe anaphylactic shock two hours after an injection of tetanus antitoxin. The patient was gravely ill and laboratory examinations showed hemoconcentration with a red blood count of 6,910,000. On this basis, he was given 2,000 cc. of physiologic solution of sodium chloride intravenously during a period of two hours, which resulted in dramatic improvement with recovery. The red blood cell count dropped to 5,700,000 at the end of this therapy, to 5,000,000 within six hours and to 4,610,000 within twelve hours of administration of saline solution.
The mechanism of action of the sulfa compounds and probable explanations for their inhibition by various factors are thoroughly discussed in recent papers by Long,4 by Kohn and Harris.' aiid by Harris and Kohn.G Presumably the same reasoning may be applied to parariitrobenzoic acid.Conclusion. The bacteriostatic effect of l)aratiitrohenzoate on the pneumococcus is markedly reduced by the products of disintegrating tissue.
From the Depnrtment of ~o o l o~/ !~ urril tlie Di/ii.sion of Dprvmtology aid ,S.yphilolo.qy, Uniuersity of Xin,mesota, and tkc. Depnrtmvit of Derrnutoloyy awl Syphilology, -If inriea pol is Gc ti ern I Hospital.r -I his report prescnts sonie prelimiiiary studies in wliicli penetration by topical application o t' various sul fonamides has heen nieasured by tissue analysis. It was thought that iontophoresis (electrolytic ion transport) iriiglit be ail effective mcaiis of forcing the aiiioti o f sulfonaniide salts into the skin. l'eiietration hy iontoplioresis was, therefore, coinpared with that from wet dressings and from ax1 ointnieiit, in the rat, ralhit, and liunian. The effect o f circulation and the depth o f penetration were estimated.Mctlzotis. The expcririimtal ani~nals were anesthetized with iieriihutal anti the liair renioved with clippci-s. Iii the ivtitophoresis cxperiments, ('anton flaiiiicl ( 6 o x grade') was wetted with the test soliitio~i a i i d applied to tlie skin. Metal gauze electrodes were firmly applied over tlie flaiiiiel as the negative p l c . The positive electrode was applied to one o f the extremities. and curretits of 1-2 tnilliamperes at 110-125 volts I>.('. were applicrl.Peiietratioii from w t dressings (gauze (11-tlaiiriel j witliout current passage, was similarly studied in coiiipar"t1)lc areas on thc same animal or on different aniiiials. 4Long, P. H., Slgnia Xi Q u , n r t~~l y , 1941, 29, 149.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.