Bacteriostatic Effect of Sulfathiazole in Various Ointment Bases

Sulfathiazole in Eczematous Pyoderma

“…The course of events was very similar in all cases : (a) the prompt development of constitutional symptoms including malaise, chilliness and elevation of temperature, (b) the local exacerbation of the lesions under treatment and (c) the generalized hematogenous "id"-like eruption, which was always pruritic and "explosive" in its onset. In many respects, the symp¬ toms are not unlike those described by Lyons and Balberor6 in a recent paper (also discussed in an edi¬ torial in The Journal.5 They described a so-called sulfonamide shock representing an acquired sensitivity to the sulfonamide as the result of oral administration 5 1941. of the drug, manifested on subsequent oral adminis¬ tration (after a five to fourteen day interval) of the same sulfonamide compound. Their evidence indicated "that approximately one third of all patients treated with sulfonamide drugs develop a sensitivity to these drugs sufficient to interfere with their subsequent use on these patients."…”

“…It is not known how long the sensitivity to sulfathiazole persists; we have not had an opportunity to determine this in any of our patients. 5. We are not certain whether these patients can take other sulfonamides by mouth without reaction.…”

“…Cutaneous tests with the chemically pure sulfonamide compound in an effort to predict reactivity are almost valueless. 5 4. The symptoms recur when sulfathiazole by mouth is resumed for a second and third time.…”