The Value of Sulfáthiazole Ointment in the Treatment of Pyogenic Infections of the Skin

Abstract

in coronary occlusion and suggested the possibility that the disturbance in the cardiac mechanism may be due to myocardial anoxemia. In man deLavergne and his associates19 noted a transitory Stokes-Adams syndrome with brachycardia eight days after the injection of antistreptococcus serum for erysipelas, at which time serum sickness developed. Also, Harkavy20 observed certain cardiac arrythmias and angina pectoris in 3 patients when offended by certain allergens. The relation of the changes in the electrocardiograms to the anaphylactic shock in our case is conjectured. Nevertheless, there were abnormally broad P waves and flat Ts shortly after the shock which returned to normal later. SUMMARY A man aged 22 had severe anaphylactic shock two hours after an injection of tetanus antitoxin. The patient was gravely ill and laboratory examinations showed hemoconcentration with a red blood count of 6,910,000. On this basis, he was given 2,000 cc. of physiologic solution of sodium chloride intravenously during a period of two hours, which resulted in dramatic improvement with recovery. The red blood cell count dropped to 5,700,000 at the end of this therapy, to 5,000,000 within six hours and to 4,610,000 within twelve hours of administration of saline solution.

Impetigo in the Services

“…Also in the U.S.A., Winer and Strakosch (1942), using 5% sulphathiazole in a water-and-oil emulsion, treated 60 children, the time of cure being 4 to 10 days; while Steigman (1942), treating 51 children-most with impetigo following scabies-found that 5% sulphathiazole in paraff. moll.…”

Clinical Toxicity of Sulfonamides

“…69-6o Systemic re-administration of a sulfonamide to patients sensitized locally tions. 42,43,[46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] Contact dermatitis (dermatitis venenata) . by previous topical application will of ten show exclusive or predominant reaction at the locally sensitized area.58, fi1-fi9…”

Cutaneous Hypersensitivity to Topical Application of Sulfathiazole

“…If sulfathiazole is continued after an interval of cessation, only minute doses need be given to ascer¬ tain whether sensitization has occurred. 5. The older methods of treatment of varicose eczema and varicose ulcer-vein injection, gelatin boot, rest and wet compresses, roentgen therapy and the like-should always be tried before sulfathiazole therapy is instituted.…”