1943
DOI: 10.1001/jama.1943.02840060024005
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Abstract: The induction of sensitivity to various sulfonamide compounds and the possible physiologic mechanisms responsible are subjects of increasing interest and importance. This paper is a report of a reaction which we have observed in 12 patients, in whom a sensitivity to sulfathiazole was apparently induced by local application of it to diseased skin, and in whom the evidence of sensitivity appeared when the drug was later administered by mouth. These patients all suffered from various forms of eczematous dermatiti… Show more

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Cited by 23 publications
(2 citation statements)
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“…62 In fact, Lowell71 recently stated that " allergic reactions were so frequent and severe in eczematous areas of the skin that the prolonged use of sulphonamides on such sites has been cautioned against repeatedly." Systemic readministration of a sulphonamide to patients sensitized locally by previous topical application will often show exclusive or predominant reaction at the locally sensitized area.70 [72][73][74][75][76][77][78][79][80] Finally, the dependence of sensitization on absorbability and tissue concentration of sulphonamides can also be inferred from the excellent and exacting study of Sulzberger and associates62 on human volunteers. These authors investigated the " incidence of dermatitis following treatment with measured amounts of different sulphonamides in the same vehicle, on standard lesions (third-degree burns), in men of the same age group, living in the same environment, on the same diets, at the same occupation, and under similar experimental conditions."…”
Section: Dosage Of Sulphonamides and Incidence Of Drug Rash And Fevermentioning
confidence: 99%
“…62 In fact, Lowell71 recently stated that " allergic reactions were so frequent and severe in eczematous areas of the skin that the prolonged use of sulphonamides on such sites has been cautioned against repeatedly." Systemic readministration of a sulphonamide to patients sensitized locally by previous topical application will often show exclusive or predominant reaction at the locally sensitized area.70 [72][73][74][75][76][77][78][79][80] Finally, the dependence of sensitization on absorbability and tissue concentration of sulphonamides can also be inferred from the excellent and exacting study of Sulzberger and associates62 on human volunteers. These authors investigated the " incidence of dermatitis following treatment with measured amounts of different sulphonamides in the same vehicle, on standard lesions (third-degree burns), in men of the same age group, living in the same environment, on the same diets, at the same occupation, and under similar experimental conditions."…”
Section: Dosage Of Sulphonamides and Incidence Of Drug Rash And Fevermentioning
confidence: 99%
“…Allergic symptoms may be released when administrating the sulphonamide by a different route than that which brought about the sensitivity; i.e. sensitization by local topical application and precipitation by ingestion or vice-versa (247,302).…”
Section: Allergy To Sulphonamidesmentioning
confidence: 99%