“…62 In fact, Lowell71 recently stated that " allergic reactions were so frequent and severe in eczematous areas of the skin that the prolonged use of sulphonamides on such sites has been cautioned against repeatedly." Systemic readministration of a sulphonamide to patients sensitized locally by previous topical application will often show exclusive or predominant reaction at the locally sensitized area.70 [72][73][74][75][76][77][78][79][80] Finally, the dependence of sensitization on absorbability and tissue concentration of sulphonamides can also be inferred from the excellent and exacting study of Sulzberger and associates62 on human volunteers. These authors investigated the " incidence of dermatitis following treatment with measured amounts of different sulphonamides in the same vehicle, on standard lesions (third-degree burns), in men of the same age group, living in the same environment, on the same diets, at the same occupation, and under similar experimental conditions."…”