Studies on Ointments

Effect of Repeated Skin Application on Percutaneous Absorption of Salicylic Acid

“…The histological changes resulting from the topical application of ointments containing salicylic acid were reported previously (11,12). The histological changes to the rat skin following treatment with salicylic acid preparations in this study were consistent with the observations of Strakosch (111, who observed that the keratolytic changes began after 2-3 days of treatment with 5 or 10% salicylic acid in an oxycholesterolpetrolatum base and after 7 days of treatment with 1% salicylic acid in this base.…”

Sulfur/Sodium Sulfacetamide Preparations

“…Sulfur has keratoplastic effects at low concentrations and keratolytic effects at higher concentrations 5 . It is believed to react with cysteine inside keratinocytes, forming cystine and releasing hydrogen sulfide 2 ; higher concentrations of sulfur therefore lead to higher amounts of hydrogen sulfide in the cells 6 .…”