Indonesia is a fertile country with various kinds of herbal plants that can grow in it. This situation has led to the widespread use of herbs in society and has even become part of Indonesian culture. There are various empirical results from the use of herbal plants in Indonesia. Luffa acutangula (gambas) is one of the many plants found in Indonesia. This plant has been widely used in helping to treat various diseases. A journal search was conducted on the pharmacological activity of Luffa acutangula in the early stages of pre-clinical trials (in vitro and in vivo) and then presented in a literature review to prove the empirical benefits of this herb. The results of potential pharmacological activities of Luffa acutangula include antimicrobial, antiparasitic, anticancer, antioxidant, antiinflammatory, antithyroid, hypoglycemic treatment, analgesic, immunomodulatory, hepatoprotective, and gastroprotective. The results of a literature review study on the pharmacological activity of Luffa acutangula show evidence of pre-clinical empirical benefits. It is hoped that by obtaining more comprehensive data like this literature study, it is hoped that it will serve to collect information on the use of Luffa acutangula as a medicinal preparation.

Latar belakang: Penyakit tuberkulosis merupakan penyakit menular dengan penyebab bakteri Mycobacterium tuberculosis. Penyakit ini dapat mengenai segala usia dan mempengaruhi semua organ Organ yang sering diserang yaitu paru-paru. Pada tahun 2016, dilakukan upaya pengobatan terhadap 55.503 pasien TB paru BTA positif di DKI Jakarta, dengan tingkat keberhasilan pengobatan terendah ditemukan di Jakarta Utara (3,99%). Oleh karena itu, penelitian ini ditujukan untuk mendapatkan faktor yang mempengaruhi rendahnya tingkat keberhasilan pengobatan TB paru di Puskesmas Lagoa. Metode: Penelitian ini menggunakan metode cross-sectional dan purposive sampling dengan sampel merupakan pasien dengan tuberkulosis paru yang telah menjalani perawatan lengkap di Puskesmas Lagoa di Jakarta Utara sebanyak 64 orang secara total sampling tahun 2017. Data diambil menggunakan kuesioner yang sudah divalidasi. Sampel merupakan pasien dengan riwayat pengobatan TB paru di Puskesmas Lagoa, berusia minimal 15 tahun, telah menyelesaikan program pengobatan selama 6 bulan di Puskesmas Lagoa, TB paru yang tinggal di wilayah kerja dari Puskesmas Lagoa. Data dianalisis menggunakan regresi logistik Hasil: Ditemukan hubungan yang signifikan antara usia, jenis kelamin, ketersediaan obat, dukungan supervisor pengobatan, dan dukungan petugas terhadap tingkat keberhasilan pengobatan penyakit TB (OR = 7,031; 95% CI 1.051-47.018). Kesimpulan: Faktor yang mempengaruhi rendahnya tingkat pengobatan penyakit TB paru adalah usia, jenis kelamin, ketersediaan obat, dukungan supervisor dan dukungan petugas dengan jenis kelamin sebagai faktor yang paling signifikan di Puskesmas Lagoa pada 2017. What Factors Affect Low Rates of Tuberculosis Treatment in Lagoa Jakarta? Abstract                        Background: Tuberculosis is an infectious disease with the cause of mycobacterium tuberculosis bacteria. This disease can affect all ages and affect all organs which the lungs are the most infected organ. In 2016, treatment efforts were made against 55,503 positive BTA pulmonary TB patients in DKI Jakarta, with the lowest treatment success rate found in North Jakarta (3.99%). Therefore, this research is aimed at obtaining factors that affect the low success rate of pulmonary TB treatment in Lagoa Health Center. Methods: This study used a cross-sectional method and purposive sampling with a sample of 64 patients with pulmonary tuberculosis who had undergone complete treatment at the Lagoa Public Health Center in North Jakarta in 2017. Data were taken using a validated questionnaire. Sample were patients with a history of pulmonary TB treatment at Puskesmas Lagoa, aged at least 15 years, had completed a 6 month treatment program at Lagoa Health Center, pulmonary TB living in the working area of Lagoa Health Center. Data analyzed using logistic regression Results: There was a significant relationship between age, sex, drug availability, treatment supervisor support, and staff support to the success rate of TB treatment (OR = 7.031; 95% CI 1.051-47.018). Conclusion: Factors affecting low rates of treatment of pulmonary TB are age, gender, drugs availability, supervisor support and support of officers. Gender is the most significant factors at Lagoa Health Center in 2017

Background: Covid-19 is a highly infectious disease. Primary prevention approaches, including personal protective measures, social distancing, and environmental surface cleaning, are required to contain disease transmission. This study aimed to investigate the compliance in implementing Covid-19 health protocols among cadres at Community Health Centre, Depok, West Java. Subjects and Method: This was a descriptive cross-sectional study conducted at Community Health Centre, Depok, West Java. A total of 73 cadres was selected for this study. The study variables were compliance on Covid-19 protocols, including mask-wearing, hand hygiene, physical and social distancing, level of education, level of Covid-19 knowledge, and other personal risk factors. The study subjects were selected by total sampling. The primary data were collected via WhatsApp group using questionnaires. The data were reported descriptively. Results: Two-third of study subjects were at age 40-50 years (61.64%). The majority of subjects were junior high school educational level (74.4%). All the study subjects complied to wear a face mask (100%). The majority of cadres possessed a high level of Covid-19 knowledge (57.53%). Most of the cadres were unemployment (72.88%). The common personal health problem was digestive problems (10.96%). Conclusion: The characteristics of cadres vary with age, educational level, level of compliance in Covid-19 protocols, work status, and level of Covid-19 knowledge. The common personal health problem among cadres is digestive problems. Keywords: compliance, Covid-19, health protocols, characteristics Correspondence: Sri Wahyuningsih. Faculty of Medicine, UPN Veteran Jakarta. Jl. Pondok Labu, Jakarta Selatan. Email: dr_sriwahyuningsih@yahoo.com. Mobile: +6281287552465. DOI: https://doi.org/10.26911/the7thicph.02.32

Diabetes has become a significant problem that has reached an alarming level. Nowadays, almost one billion people around the world live with diabetes. In 2019, Indonesia occupied the seventh position in the world with 10,7 million people live with diabetes. Although various antihyperglycemic agents are available, diabetes is still a significant problem in the world. Siam weed (Chromolaena odorata L.) is widely used in Indonesia and traditional medicine to treat diabetes. This study aimed to determine the phytochemical content of C. odorata extract and analyze the effectiveness of the anti-diabetic of C. odorata extract in lowering blood sugar levels. The method used in this study is a systematic review with journals derived from the online databases of PubMed and Google Scholar. The journals used are journals that discuss C. odorata, extract, anti-diabetic, and blood sugar. Journal search results show, eight studies explain the potential anti-diabetic activity of C. odorata extract in lowering blood sugar levels. Data synthesis from several studies shows that C. odorata extract has potential anti-diabetic activity because it contains phytochemicals in the form of alkaloids, flavonoids, phenols, saponins, and tannins which are potent antioxidants and cytoprotectants that can lower blood sugar levels.

Kesehatan penting untuk dijaga dan pencegahan penyakit dengan menjaga kesehatan lebih baik daripada mengobati penyakit. Masyarakat Depok, Jawa Barat termasuk daerah yang subur namun cukup padat penduduknya sehingga lahan untuk menanam tanaman, termasuk TOGA terbatas. Untuk memotivasi masyarakat menanam TOGA, diperlukan pelatihan membuat minuman kesehatan yang dapat dilakukan secara mandiri untuk menjaga kesehatan sehari hari secara sederhana. Pelatihan pembuatan minuman kesehatan dapat lebih memotivasi masyarakat untuk menanam TOGA di pekarangan sekitar rumah. Pelatihan ini sebelumnya didahului dengan penyuluhan tentang TOGA dan manfaatnya terutama kunyit (Curcuma domestica) dan jahe merah (Zingiber officinale L). Pelatihan ini bertujuan agar masyarakat dapat lebih paham tentang pentingnya menanam TOGA, pemanfaatannya dalam menjaga kesehatan sehari hari dan dapat membuat minuman kesehatan. Dengan pelatihan ini juga diharapkan masyarakat dapat lebih mencegah penyakit daripada mengobati penyakit, dengan mengkonsumsi minuman kesehatan yang dibuat secara mandiri. Hasil yang dicapai dari kegiatan ini adalah meningkatnya pengetahuan masyarakat di RW 03 Depok Jaya Pancoran Mas Depok tentang pentingnya menanam TOGA di pekarangan rumah, dan mampu membuat minuman kesehatan berupa kunyit asam dan serbuk jahe merah.

Objective: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation in joints. Ageratum conyzoides L. (Babandotan) leaves are proven to be used in inflammation therapy, yet there is a little data regarding the effects of the leaves on RA. The aim of this study is to investigate anti-RA activity of the ethanolic extract of A. conyzoides L. leaves (EEAL) harvested from Bogor, Indonesia, in rats. Methods:The phytochemical screening analysis and thin-layer chromatography were performed to analyze the constituents of the EEAL. This study used white male Sprague Dawley rats which were divided into 6 groups; normal control and negative control groups, both given 0.5% carboxymethyl cellulose; the positive control group, given methotrexate suspension (0.05 mg/200 g bw.); the dose variation extract is 40 mg, 80 mg, and 160 mg/200 g body weight. All the groups were induced with 0.1 ml Complete Freund's adjuvant on day 1, except normal control group. Some parameters will be measured, such as paw edema, levels of leukocyte and lymphocyte, concentrations of tumor necrosis factor-α (TNF-α), and the number of osteoclasts per mm 2 .Results: For 21 days the rats have given treated the EEAL in three doses, was showed the decreasing volume of paw edema, levels of blood leukocytes and lymphocytes, concentrations of TNF-α and the number of osteoclasts, compared to the rat model of RA. Conclusion:This study showed that the leaves of A. conyzoides L. harvested from Bogor, Indonesia, have activity as anti-RA in a rat model, in which flavonoid plays a role in inhibition of chronic inflammatory processes.

Contact dermatitis is considered trivial for some people. There are many environmental factors could be the main factors causing contact dermatitis on salted-fish processor in Pengolahan Hasil Perikanan (PHPT) or Fishery Processing Area of Muara Angke such as water, temperature, fish, and humidity. These were due to the geographical location of the coastal determine the environmental factors which related to the contact dermatitis suspected on salted-fish processor in the PHPT Muara Angke area. The study was analytic observational with cross sectional design, with subjects were 112 samples. Results showed that 53,6% of salted-fish processor were suspected contact dermatitis. The suspected contact dermatitis increased by poor length of contact (OR= 9.42, 95% CI= 2.91 to 30.53, p=0,000), poor frequency of contact (OR= 4.70, 95% CI= 1.10 to 20.20, p=0,000), and bad temperature (OR= 3.74, 95% CI= 1.34 to 10.45, p=0,003). The length of contact can makes the lack of permeability of the skin, so the material of irritant can infiltrate properly. To prevent contact dermatitis the distribution of clean water must be comprehensive and do as the standards. The building of the processing room has to protect the worker from the heat temperature. Personal hygiene and personal protective must be increase to protect the worker from disease and to keep the quality of the product.

ENHANCING OF ANC AND UTILIZATION OF TOGA IN PREGNANCY AT SAWANGAN DEPOK. Women’s and children’s health problems today remain a global challenge and need remedial action. Maternal death is the death of a woman during pregnancy or death within 42 days of termination of pregnancy. Antenatal care (ANC) is an attempt to prevent the causes of morbidity and mortality in pregnant women and children. During pregnancy various physiological changes occur in pregnant women, this certainly has an impact on the psychology and health of pregnant women. TOGA (Family medicinal plants) can be used to help overcome this uncomfortable situation. Plants that can be used by pregnant women include, such as ginger, red spinach, red betel, green betel, tomatoes, and broccoli. There is a possibility of abnormalities such as bleeding, preeclampsia, and infection during pregnancy. Therefore there is a need for monitoring in the form of Antenatal Care during pregnancy and the mother’s understanding of early detection of the risk of abnormalities during pregnancy. This community service is carried out to increase community knowledge around the Sawangan Depok Community Health Center about the importance of ANC and the use of TOGA in pregnant women as well as training in the introduction of several abnormalities and emergencies during pregnancy through counseling with lecture media, pamphlets and pocketbooks on ANC and the use of TOGA. This activity went well and the results can be seen there is an increase in the results of the posttest compared to the pretest, and statistically, there are significant differences.