Dyslipidemia is a coronary heart disease risk factor. Dyslipidemia is characterized by the elevated levels of LDL, triglycerides, total cholesterol, and the decrease in HDL. Ginger rhizome (Curcuma xanthorriza Roxb.) and bay leaf (Eugenia polyantha Wight.) are local plants that have the abilities to decrease total cholesterol. This research design was true experimental with pre- and post-control group design. Criteria of sample were white rats, wistar strain, male, age of 8-12 weeks, and body weight range of 150-200 grams. Sampling method was simple random sampling. The experimental rats were acclimatized for seven days. Hypercholesterol diet was fed two weeks, and then the rats were given intervention and get hypercholesterol diet for two weeks. During intervention, the experimental rats were divided into 6 groups of administrationi.e, rats administered with 1) carboxymethil celluse/CMC, 2) simvastatin 0,9 mg/kg BW/day, 3) ginger rhizome extract 200 mg /kg BW/day, 4) ginger rhizome extract 400 mg/kg BW/day, 5) bay leaf extract 200 mg/kg BW/day, and 6) bay leaf extract 400 mg/kg BW/day. Blood samples were taken from caudal vein and total cholesterol levels were measured by spectrophotometry. The analysis used paired T test, One Way ANOVA test. The results showed ginger rhizome extract did not effectively reduce total cholesterol. However, bay leaf extract effectively decreased total cholesterol levels with the highest total cholesterol reduction was found in rats administered with dose of 400 mg/kg BW/day i.e, 15.4 mg/dl. Bay leaf extract have the same effectivity with simvastatin as a standard drug in lowering cholesterol level.
Background: Stroke causes severe disability and mortality. Despite the fact that the pathology of acute stroke is well understood, publication on chronic stroke is still limited. Because scarring of glia limits the recovery area of acute stroke and reorganization capacity is reduced, discovering new treatments for chronic stroke poses substantial obstacles. In stroke research, rodent models are commonly utilized, and behavior testing is a crucial tool. To measure stroke outcomes and translating rodent findings to therapeutic trials, selecting relevant behavioral tests that fit the study purpose is critical. Here, we aimed to look at the last decade’s publications highlighting behaviour tests on chronic stroke rats. Hopefully, we were able to give more information about the behaviour tests to facilitate the researchers’ choice of appropriate test. Methods: By using a bibliometric analysis, we hope to systematically discuss rodent behavior tests in chronic stroke research. Documents were extracted from the Scopus database in April 2022. Excel and VOSviewer 1.6.18 were used to conduct statistical and graphical analysis. Results: Research on "behavioral test in chronic stroke rats" has progressed quickly, although the researchers have yet to collaborate with each other. H. Millani was an active researcher and author who connected numerous researchers, according to documents and citation analysis. “Animals”, “brain ischemia”, “man”, “publication”, and “animal experiment” were all common keywords. The majority of the articles were from the United States and China. The Morris Water Maze test and the cylinder test were the most commonly used behavior tests. Conclusions Clinical applications and therapeutic effectiveness against stroke could be improved with more collaboration amongst authors. When using a behavior test, researchers need to think about which neurological deficiency is being addressed and whether the test covers long-term evaluation.
ENHANCING OF ANC AND UTILIZATION OF TOGA IN PREGNANCY AT SAWANGAN DEPOK. Women’s and children’s health problems today remain a global challenge and need remedial action. Maternal death is the death of a woman during pregnancy or death within 42 days of termination of pregnancy. Antenatal care (ANC) is an attempt to prevent the causes of morbidity and mortality in pregnant women and children. During pregnancy various physiological changes occur in pregnant women, this certainly has an impact on the psychology and health of pregnant women. TOGA (Family medicinal plants) can be used to help overcome this uncomfortable situation. Plants that can be used by pregnant women include, such as ginger, red spinach, red betel, green betel, tomatoes, and broccoli. There is a possibility of abnormalities such as bleeding, preeclampsia, and infection during pregnancy. Therefore there is a need for monitoring in the form of Antenatal Care during pregnancy and the mother’s understanding of early detection of the risk of abnormalities during pregnancy. This community service is carried out to increase community knowledge around the Sawangan Depok Community Health Center about the importance of ANC and the use of TOGA in pregnant women as well as training in the introduction of several abnormalities and emergencies during pregnancy through counseling with lecture media, pamphlets and pocketbooks on ANC and the use of TOGA. This activity went well and the results can be seen there is an increase in the results of the posttest compared to the pretest, and statistically, there are significant differences.
Kadar asam urat tinggi dapat meningkatkan stres oksidatif di ginjal yang menyebabkan kerusakan glomerulus dan iskemia tubular. Ekstrak bunga kamboja (Plumeria rubra) mengandung kadar flavonoid tinggi yang dapat mencegah stres oksidatif dan menurunkan kadar asam urat. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak P. rubra terhadap fungsi ginjal pada tikus model hiperurisemia. Penelitian dilakukan pada bulan Februari – Maret 2020 di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Universitas Padjajaran Bandung. Desain penelitian adalah eksperimental menggunakan tikus Rattus novergicus sebanyak 30 ekor yang dibagi dalam 5 kelompok dengan 6 tikus pada masing-masing kelompok. Kelompok kontrol terdiri atas kelompok 1 (kontrol negatif) dan kelompok 2 (kontrol positif dengan alopurinol ), kelompok 3, 4 dan 5 yang masing-masing mendapatkan dosis ekstrak P. rubra 200, 400 dan 600 mg/KgBB/hari. Penelitian dilakukan selama 14 hari dengan intervensi pada minggu pertama berupa induksi dan seminggu selanjutnya perlakuan. Sampel darah diambil melalui ekor tikus untuk menilai kadar asam urat dan kreatinin. Data dianalisis dengan uji Kruskall-Wallis. Hasil yang berbeda bermakna terdapat pada dosis 200, 400 dan 600 mg terhadap kadar asam urat (nilai p=0,004, 0,008 dan 0,004) sedangkan pada kreatinin perbedaan bermakna terdapat pada dosis 200 dan 400 mg (nilai p=0,004 dan 0,042). Terdapat penurunan signifikan pada kadar kreatinin setelah pemberian ekstrak P. rubra 400 mg/KgBB/hari yang berarti dapat memperbaiki fungsi ginjal tikus hiperurisemia. Kata kunci: fungsi ginjal, P. rubra, hiperurisemia, potasium oksonat dan antioksidan. The Effect of Plumeria rubra Extract on Kidney Function in Hyperuricemic Rat Model Abstract Hyperuricemia can increase oxidative stress in kidney which will cause glomerular damage and tubular ischemia. Frangipani flower extract (Plumeria rubra) contains high amounts of phenols and flavonoids which can prevent the formation of oxidative stress and can reduce uric acid levels. This study aims to determine the effect of frangipani flower extract on kidney function in white rats induced by potassium oxonate. This research was conducted in February – March 2020 at the laboratory of pharmacology and therapy, faculty of medicine, Universitas Padjajaran, Bandung. The design of this study was experimental using 30 Rattus novergicus rats divided into 5 groups with 6 mice in each group. The control group consisted of group 1 (negative control) and group 2 (positive control with alopurinol ). The treatment group consisted of groups 3, 4, and 5, which were variations in doses of P. rubra extract 200, 400, and 600 mg/KgBB /day. The study was conducted for 14 days with the first week of induction and a week later of treatment. Blood samples are taken through the tail to assess uric acid and creatinine levels. The study was analyzed using Kruskall-Wallis. The results of significant differences were found at doses of 200, 400 and 600 mg of uric acid levels (p-value 0.004, 0.008 and 0.004) while the mean creatinine differences were found at doses of 200 and 400 mg (p-values 0.004 and 0.042). In this study, a significant decrease in creatinine levels after treatment showed that there was an effect of P. rubra extract on kidney function with an effective dose of 400 mg/kg/day. Keywords: kidney function, P. rubra, hyperuricemia, potassium oxonate and antioxidants.
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