The study is aimed at evaluating the fertility potential of bi-herbal methanol extract on male Wistar rats. This research finding based it fact of fertility in male Wistar rats to investigate through the phytochemicals, antioxidant assay, hormonal indexes, lipid profile, body/organ weight changes and histopathological study across the graded doses (25, 50, 100 mg/kg) of the treated groups of bi-herbal (Zingiber officinale and Chrysophyllum albidum)) methanol extract using standard procedure. Results from the phytochemical screening elicited the essential constituents (alkaloids, flavonoids phenol, tannins and saponnins). The antioxidant assay showed broad scavenging property against free radicals, which possibly is associated with one of its mechanisms of action. An increase in the level of significant (p > 0.05) in hormonal indexes (testosterone, progesterone, follicle stimulating hormone and luteinizing hormone) and slight increase in the level of lipid profile (cholesterol, triglyceride, HDL LDL and VLDL) activities among the treatment groups when compared with the control. There absent significant change (p > 0.05) in the body and testes mass ratio. No pronounce histopathological variation on the testes state in comparative to the control. The dependent from the bi-herbal extract with extreme exhibition of fertility potential as its therapeutic effect
This study is aimed at evaluating the anti-diabetes property of Chrysophyllum albidum on Streptozotozininduced Diabetic mellitus in rats. Diabetic mellitus induced intraperitoneally with streptozotocin (STZ) using standard dose of 40 mg/kg after fasted for 12 hours as protocol implies. Blood glucose levels were determined using Accu-check glucometer before and during treatment of 10 and 30 mg/kg C. albidum when compared with Metformin and diabetic control groups. Animals whose blood glucose level was above 200 mg/dL were considered diabetic. After 28 days of treatment, blood and tissue samples were isolated for fasting blood sugar, haematological, bioassay and histopathological study using standard procedures. Result revealed a significant decrease (p<0.05) in the treated groups specifically at 30 mg/kg body C. albidum ethanol extract when compared with metformin and diabetic control group from weeks 0 to 5. The haematological result showed slight significant difference (p>0.05) now some parameters across treated groups excluding 10 mg/kg of C. albidum of MCH that showed a significant difference when compared with metformin and control group. Result showed a significant increase in the level of CAT, SOD, MDA and GST across the treated groups (10 and 30 mg/kg C. albidum) ethanol extract when compared with standard (10 mg/kg metformin) and diabetic control. The histopathological alteration observed in this study include; severe interlobular oedema and fatty droplets in the interlobular ducts and connective tissues. These alterations were prominent in the diabetic control group while 30 mg/kg of C. albidum showed prominent reduction in damage done by an anti-diabetonic agent (streptozotocin). This study showed that C. albidum is effective in the management of diabetes, which concord with its ethnomedicinal reports.
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