The phytochemical constituents and the antiulcerogenic activity of methanolic extract from Ipomoea asarifolia leaf were investigated to ascertain its medicinal potentials. The study revealed that the leaf contained saponins, tannins, alkaloids, terpenoids and eugenols. The methanolic extract was used as a protective agent against gastric ulcer in Wistar rats, using the experimental model of gastric ulcer (lesion) induced by ethanol. The ulcer count for the methanol extract ranged from 0.00 to 2.00, while the ulcer index ranged between 0.33 to 2.00 for all concentrations (100, 200 and 400mg/kg). Percentage inhibition at 100, 200 and 400mg/kg were respectively 25.09%, 12.73% and 87.64%. The extract prevented acute gastric mucosal injury induced by absolute ethanol in a non dose-dependent manner. This is because the protective action was observed at the lowest and highest doses, but not an intermediate dose of the extract. The results obtained indicate that the leaf extract has antiulcerogenic importance and may be utilized for the treatment of gastric ulcers.

The study is aimed at evaluating the fertility potential of bi-herbal methanol extract on male Wistar rats. This research finding based it fact of fertility in male Wistar rats to investigate through the phytochemicals, antioxidant assay, hormonal indexes, lipid profile, body/organ weight changes and histopathological study across the graded doses (25, 50, 100 mg/kg) of the treated groups of bi-herbal (Zingiber officinale and Chrysophyllum albidum)) methanol extract using standard procedure. Results from the phytochemical screening elicited the essential constituents (alkaloids, flavonoids phenol, tannins and saponnins). The antioxidant assay showed broad scavenging property against free radicals, which possibly is associated with one of its mechanisms of action. An increase in the level of significant (p > 0.05) in hormonal indexes (testosterone, progesterone, follicle stimulating hormone and luteinizing hormone) and slight increase in the level of lipid profile (cholesterol, triglyceride, HDL LDL and VLDL) activities among the treatment groups when compared with the control. There absent significant change (p > 0.05) in the body and testes mass ratio. No pronounce histopathological variation on the testes state in comparative to the control. The dependent from the bi-herbal extract with extreme exhibition of fertility potential as its therapeutic effect

The aim of this experiment was to determine the phytochemical screening and histopathological property of Moringa oleifera Lam. root ethanol extract in Wistar rats. The qualitative phytochemical screening was experimented using standard protocol. The animals were randomly divided into groups seven (n=5). Cadmium chloride (3.6 mg/kg) was administered across the groups for 7 days to established bio-toxicity. There after graded doses of the treatment groups (100, 200 and 400 mg/kg) and the control groups were treated for another two (2) weeks to remediate the deposition of cadmium toxicity. The animals were sacrificed and the targeted visceral organs (heart, lungs, liver and kidney) were isolated and prepared for histopathological analysis. The phytochemical results showed the presence of alkaloids, tannins, saponnins, flavonoids, phenol, anthraquinone and carbohydrate. The histopathological study elicited from the treatment revealed an ameliorative effect from the damage organs triggered by cadmium chloride, enhance displayed cardio-protective, reno-protective, hepato-protective and brochio-protective effect when compared with untreated control. The study showed that graded doses (100, 200 and 400 mg/kg) of the extract had a significant effect in the targeted organs against cadmium chloride toxicity.

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