Phytochemical and Antimicrobial Properties of Chrysophyllum albidum, 
Dacryodes edulis, Garcinia kola chloroform and ethanolic root extracts

Idu, MacDonald; Obayagbona, Nosa Omoregbe; Oshomoh, Emmanuel Ola; Erhabor, Joseph O.

doi:10.5455/jice.20140109033957

“…This demonstrate that the active antimicrobial contents of the root of G.kola are from the polar/nonpolar intermediate solvents. This is consonant with the finding of Idu and colleagues on the CHCl3 root extract activity of G.kola on staph aureus (Idu et al, 2014).…”

Section: Discussionsupporting

confidence: 87%

Antibacterial Activity of the Root Extracts of Garcinia Kola Against MDR Staphylococcus Aureus : Invitro and Insilico Studies

Yakubu

¹

,

Muhammad²

2021

Preprint

0

View full text Add to dashboard Cite

MDR Staphylococcus aureus is an important bacteria with clinical and economic implication. Plants including Garcinia kola provides bioactive principles with diverse structural and biological features.. The n-Butanol fraction of G.kola root extract recorded the highest activity against MDR staph aureus (18.50±0.41) compared to the chloroform (10.00±2.12) and methanol (8.166±0.62) extarct, with no activity recorded with the n-Hexane extract. Analysis of this fraction on GC-MS recorded 14 phytoconstituents with varying structural composition; containing important scaffolds & motifs of benzoquinone, <a href="https://pubchem.ncbi.nlm.nih.gov/compound/imidazo[1,2-a]pyridine">imidazo[1,2-a]pyridine</a>, Chlorocarbazole and azetidine that present key pharmaceuticals as antibiotic and for drug development. Further inslico molecular docking studies of these compounds on antibacterial drug target; Tyrosyl-tRNA synthetase (PDB 1JIJ) from MDR staph aureus was documented. 9 compounds (CID_619544, CID_619583, CID_5732, CID_616643, CID_622021, CID_ 616496, CID_590350, CID_16486 and CID_66747) had good binding scores ranging from -4.63 to -7.08 kcal/mol; with CID_590350 having the highest score. The compounds formed various bonding with the 1JIJ amino acid residues including H-bond, van der waal and π interactions. CID_16486 and CID_66747 bind to the most active binding pocket (Drug score: 0.82 &0.72) while CID_619583 tend to bind outside the active binding pocket. They also have good pharmacokinetic and toxicity profile. Therefore, these compounds are considered as suitable prospective antibiotics against MDR Staphylococcus aureus after successful invitro and insilico experimental validation.

show abstract

“…The percentage ash content of Chrysophyllum albidum seed cotyledons which was obtained from the proximate analysis as shown in table 4 is 1.90%. This is higher than 1.40% as reported by [23] but slightly lesser than 2.62% and 3.80% reported by [25,26] consistently. The ash content shows the presence of carbon compounds and inorganic component in the form of salt and oxides in the seed of Chrysophyllum albidum.…”

Section: Chemical Compositioncontrasting

confidence: 66%

“…The percentage carbohydrate observed from the proximate analysis of the seed cotyledons was 67.65 % as displayed in table 4. The value is significantly higher than 60.39% previously reported by [27] but lower than 70.60% and 71.40% respectively reported [25,26]. These analysis shows that the C. albidum seed can serve as food and can also give energy as it is a very good source of carbohydrate.…”

Section: Chemical Compositioncontrasting

confidence: 54%

“…The proximate study of C. albidum seed cotyledons as shown in table 4 reveals the composition of nutrients classified in percentages. The percentage moisture content of the seed obtained from the analysis as shown in table 4 is 14.98%, this value is above 9.0% and 9.39% reported by [25,26]. The value is meaningfully lesser than 24.17% as found by [27].…”

Section: Chemical Compositionmentioning

confidence: 56%

See 1 more Smart Citation

Exploring the Antimicrobial Activities of Chrysophyllum albidum Seed oil in Pharmaceutical and the Seeds in Food industry.

Olabanji

¹

,

Akinkunmi

²

,

O

³

et al. 2021

J. Food Pharm. Sci

0

View full text Add to dashboard Cite

The anti- microbial activity tests of the seed oil, NaOH and ash soaps of the seed oil, of C.albidum were carried out to determine their effectiveness against gram+, gram– bacteria and some fungi strains. The proximate analysis of C.albidum seeds was performed to determine its nutritional benefits to mankind. Agar diffusion tests using Disc diffusion for the pure oils and soaps while the cup plate test method for dilutions was used in the determination of in-vitro activities. Standard methods as described by AOAC, (1990); AOAC, (1984) and Kjeldahl method described by Chang (2003) were used for proximate determinations. The results show the activity of the oil against Klebsiella pneumonia at a concentration as low as 10 mg/ml. The ash-soap of the leaves shows the highest antimicrobial activities because its MIC is the closest to the standard, Streptomycin. It possesses activity against Escherichia coli and Klebsiella pneumonia at a concentration as low as 5mg/ml. The % proximate analysis composition shows Moisture content, Ash content, Crude Fibre, fat/Oil, Protein, Carbohydrates as follows (14.98, 1.90, 2.09, 2.38, 12.14 and 67.65)%. The study concluded by unleashing the great potential of Chrysophyllum albidum seeds as a useful raw material in food, cosmetics and pharmaceutical industries rather than being regarded as waste in the environment

show abstract

“…ADME/TOX program (Lipinski et al, 2001) and DataWarrior tool (Sander et al, 2015). (Idu et al, 2014).…”

Section: Drug Likeness and Pharmacokinetics Analysismentioning

confidence: 99%

Antibacterial Activity of the Root Extracts of Garcinia Kola Against MDR Staphylococcus Aureus : Invitro and Insilico Studies

Yakubu

¹

,

Muhammad²

2021

Preprint

0

View full text Add to dashboard Cite

MDR Staphylococcus aureus is an important bacteria with clinical and economic implication. Plants including Garcinia kola provides bioactive principles with diverse structural and biological features.. The n-Butanol fraction of G.kola root extract recorded the highest activity against MDR staph aureus (18.50±0.41) compared to the chloroform (10.00±2.12) and methanol (8.166±0.62) extarct, with no activity recorded with the n-Hexane extract. Analysis of this fraction on GC-MS recorded 14 phytoconstituents with varying structural composition; containing important scaffolds & motifs of benzoquinone, <a href="https://pubchem.ncbi.nlm.nih.gov/compound/imidazo[1,2-a]pyridine">imidazo[1,2-a]pyridine</a>, Chlorocarbazole and azetidine that present key pharmaceuticals as antibiotic and for drug development. Further inslico molecular docking studies of these compounds on antibacterial drug target; Tyrosyl-tRNA synthetase (PDB 1JIJ) from MDR staph aureus was documented. 9 compounds (CID_619544, CID_619583, CID_5732, CID_616643, CID_622021, CID_ 616496, CID_590350, CID_16486 and CID_66747) had good binding scores ranging from -4.63 to -7.08 kcal/mol; with CID_590350 having the highest score. The compounds formed various bonding with the 1JIJ amino acid residues including H-bond, van der waal and π interactions. CID_16486 and CID_66747 bind to the most active binding pocket (Drug score: 0.82 &0.72) while CID_619583 tend to bind outside the active binding pocket. They also have good pharmacokinetic and toxicity profile. Therefore, these compounds are considered as suitable prospective antibiotics against MDR Staphylococcus aureus after successful invitro and insilico experimental validation.

show abstract

Phytochemical and Antimicrobial Properties of Chrysophyllum albidum, Dacryodes edulis, Garcinia kola chloroform and ethanolic root extracts

Cited by 11 publications

References 0 publications

Antibacterial Activity of the Root Extracts of Garcinia Kola Against MDR Staphylococcus Aureus : Invitro and Insilico Studies

Antibacterial Activity of the Root Extracts of Garcinia Kola Against MDR Staphylococcus Aureus : Invitro and Insilico Studies

Exploring the Antimicrobial Activities of Chrysophyllum albidum Seed oil in Pharmaceutical and the Seeds in Food industry.

Antibacterial Activity of the Root Extracts of Garcinia Kola Against MDR Staphylococcus Aureus : Invitro and Insilico Studies

Contact Info

Product

Resources

About