Antidiabetic property of Chrysophyllum albidumextract in Streptozotozin- induced diabetic rats

Abstract

This study is aimed at evaluating the anti-diabetes property of Chrysophyllum albidum on Streptozotozininduced Diabetic mellitus in rats. Diabetic mellitus induced intraperitoneally with streptozotocin (STZ) using standard dose of 40 mg/kg after fasted for 12 hours as protocol implies. Blood glucose levels were determined using Accu-check glucometer before and during treatment of 10 and 30 mg/kg C. albidum when compared with Metformin and diabetic control groups. Animals whose blood glucose level was above 200 mg/dL were considered diabetic. After 28 days of treatment, blood and tissue samples were isolated for fasting blood sugar, haematological, bioassay and histopathological study using standard procedures. Result revealed a significant decrease (p<0.05) in the treated groups specifically at 30 mg/kg body C. albidum ethanol extract when compared with metformin and diabetic control group from weeks 0 to 5. The haematological result showed slight significant difference (p>0.05) now some parameters across treated groups excluding 10 mg/kg of C. albidum of MCH that showed a significant difference when compared with metformin and control group. Result showed a significant increase in the level of CAT, SOD, MDA and GST across the treated groups (10 and 30 mg/kg C. albidum) ethanol extract when compared with standard (10 mg/kg metformin) and diabetic control. The histopathological alteration observed in this study include; severe interlobular oedema and fatty droplets in the interlobular ducts and connective tissues. These alterations were prominent in the diabetic control group while 30 mg/kg of C. albidum showed prominent reduction in damage done by an anti-diabetonic agent (streptozotocin). This study showed that C. albidum is effective in the management of diabetes, which concord with its ethnomedicinal reports.