The influence of 9α-fluoro,16α-methylprednisolone, 6α-fluoroprednisolone, and 6α-methylprednisolone on 47Ca utilization was studied in young beagle dogs. The major effect of steroid therapy, with each dog as his own control, is to increase 47Ca eliminated in the faeces and urine.
Based on mean treated/control ratios 9α-fluoro,16α-methylprednisolone causes 2.5 to 10 times more inhibition of utilization of radio-calcium than equivalent doses of 6α-fluoroprednisolone or 6α-methylprednisolone.
The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.
The giant cell of osteoclastic origin and the giant cell produced in response to foreign bodies are characterized by multiple nuclei. Electron microscopy of these multinucleated cells reveals a special centrosphere in the osteoclast, which is not typical of other types of giant cells.
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