Giant-Ceil Centrioles

Matthews, James L.; Martin, J. Holmes; Race, George J.; Collins, Elliott J.

doi:10.1126/science.155.3768.1423

Cited by 37 publications

(11 citation statements)

References 6 publications

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“…Centriolar apparatus was also observed in the multinucleated mammalian cells e osteoclasts, osteoclastomas, and granulomas in infected tissues. In the osteoclasts the centrioles were assembled in special structures e centrospheres, the number of centriole pairs being equal to the number of the cell nuclei (Mattews et al, 1967).…”

Section: Discussionmentioning

confidence: 99%

Whole-genome chromosome distribution during nuclear fragmentation of giant trophoblast cells of Microtus rossiaemeridionalis studied with the use of gonosomal chromatin arrangement

Zybina

Bogdanova

et al. 2005

Cell Biology International

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Gonosomal chromatin bodies (GCBs), i.e. blocks of condensed chromatin consisting of heterochromatized region of the sex chromosomes of the field vole M. rossiaemeridionalis, were used as a natural interphase chromosome marker in order to clarify the regularities of GCB rearrangement during nuclear fragmentation of secondary giant trophoblast cells (SGTCs) at the end of their differentiation. Cytophotometrical measurements of DNA content in the nuclei, nuclear fragments and simultaneously in the GCBs were made in the secondary giant SGTCs of field vole M. rossiaemeridionalis. In most cases 1 to 2 GCBs get into the nuclear fragments at different ploidy levels. In the nuclear fragments, GCB DNA content decreased mostly proportionally to DNA content in the whole fragments corresponding to 2c, 4c and 8c. The data obtained demonstrate a regular whole-genome chromosome distribution into nuclear fragments. A possible mechanism of nuclear fragmentation that largely ensures a balanced genome in nuclear fragments is discussed.

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Section: Discussionmentioning

confidence: 99%

Whole-genome chromosome distribution during nuclear fragmentation of giant trophoblast cells of Microtus rossiaemeridionalis studied with the use of gonosomal chromatin arrangement

Zybina

Bogdanova

et al. 2005

Cell Biology International

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“…The appearance of the mitochondria, the presence of innumerable vesicles near the nuclear and the cytoplasmic membrane, the abundance of glycogen particles are all signs of metabolic disorders in the osteoclasts found in Paget's disease (8,34,35). Similarly, the presence of multiple basal bodies and the aspect of the cell membrane infolding suggest an abnormal increase in the surface activity and the motility of these cells (8,21,36,37).…”

Section: Thementioning

confidence: 99%

Bone tissue in paget's disease of bone ultrastructure and immunocytology

Rèbel

Basle

Pouplard

et al. 1980

Arthritis & Rheumatism

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Ultrastructural observations in Paget's disease of bone clarify aspects of bone cells in bone tissue and demonstrate the presence of specific intranuclear inclusions composed of microcylinders in the osteoclasts. The morphologic analysis of these structures suggests an analogy with virus material of the measles group. Results obtained using indirect immunofluorescence and immunoperoxidase techniques lend further support to the hypothesis of a viral etiology in Paget's disease of bone.

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“…A distinctive morphological feature of osteoclasts, compared with other multinucleated cells, is the arrangement of their multiple centrioles in a single grouping away from the nuclei (Matthews et al 1967, Lucht 1973. The structure of the centrioles them-selves is identical to that found in most other cell types, and as with other giant cells, the number of centriole pairs corresponds to the number of nuclei.…”

Section: The Evidence For Current Views Of the Origin Of Osteoclmentioning

confidence: 88%

“…It is the association of all centrioles into a giant centrosphere, rather than dispersion within the cell, that is unique. It has been suggested (Matthews et al 1967) that this feature may be related to the fate or mechanism of formation of osteoclasts. While some giant cells can form, by cell division (Sutton & Weiss 1966), osteoclasts do not.…”

Section: The Evidence For Current Views Of the Origin Of Osteoclmentioning

confidence: 99%

The origin of osteoclasts:

1983

J Oral Pathology Medicine

152

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Recent evidence for an extraskeletal origin of osteoelasts and the historical record of the genesis of osteoelasts are examined critically. Reviews of the structure, function and development of osteoelasts from mononuclear precursors, the local regulation of bone resorption and the coupling of bone formation to preceding resorption are presented as a background for discussing the clinical implications for management of osteolytic bone diseases. The roles of osteoelasts and macrophages as phagocytes are compared and contrasted, and recent evidence for macrophage heterogeneity resulting from site-specific monoblastic precursors is reviewed. The implications of these recent developments in macrophage biology are extrapolated to osteoelasts and the existence of site-specific, extraskeletal tsteoclast precursors is proposed. Finally, the investigative challenges inherent in these perspectives are discussed.

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Giant-Ceil Centrioles

Abstract: The giant cell of osteoclastic origin and the giant cell produced in response to foreign bodies are characterized by multiple nuclei. Electron microscopy of these multinucleated cells reveals a special centrosphere in the osteoclast, which is not typical of other types of giant cells.

Cited by 37 publications

References 6 publications

Whole-genome chromosome distribution during nuclear fragmentation of giant trophoblast cells of Microtus rossiaemeridionalis studied with the use of gonosomal chromatin arrangement

Whole-genome chromosome distribution during nuclear fragmentation of giant trophoblast cells of Microtus rossiaemeridionalis studied with the use of gonosomal chromatin arrangement

Bone tissue in paget's disease of bone ultrastructure and immunocytology

The origin of osteoclasts:

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