The influence of 9α-fluoro,16α-methylprednisolone, 6α-fluoroprednisolone, and 6α-methylprednisolone on 47Ca utilization was studied in young beagle dogs. The major effect of steroid therapy, with each dog as his own control, is to increase 47Ca eliminated in the faeces and urine. Based on mean treated/control ratios 9α-fluoro,16α-methylprednisolone causes 2.5 to 10 times more inhibition of utilization of radio-calcium than equivalent doses of 6α-fluoroprednisolone or 6α-methylprednisolone.

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