An Experimental Study of Pseudopregnancy in Rat

Swingle, W. W.; Seay, Patrick H.; Perlmutt, Joseph H.; Collins, Elliott J.; Barlow, George; Fedor, E. J.

doi:10.1152/ajplegacy.1951.167.3.586

Cited by 24 publications

(12 citation statements)

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“…This finding is in general agreement with the experimental evidence reviewed by Parkes [1945], pointing to the importance of giving adrenal¬ ectomized animals salt therapy if the cessation of oestrous cycles is to be prevented. The results are at variance, however, with those of Swingle, Fedor, Barlow, Collins & Perlmutt [1951], who reported that a high proportion of adrenalectomized animals maintained on salt therapy became pseudopregnant. The authors suggest that in the rat, the removal of the adrenal glands in some way stimulates the pituitary to release sufficient LH which, in its turn, activates corpora lutea to secrete progesterone.…”

Section: Ovarian Changes After Adrenalectomy (Series I) Ovarian Weightsmentioning

confidence: 54%

The Sensitivity of Adrenalectomized Rats to Gonadotrophins

Mandl¹

1954

Journal of Endocrinology

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The sensitivity of adrenalectomized, control-operated and unoperated rats to pregnant mare serum (PMS) and chorionic gonadotrophin (CG) has been studied. A total of 638 mature and immature female rats was used.The ovaries of adrenalectomized rats were found to contain fewer large follicles and corpora lutea than those of control-operated litter-mates, and the slight ovarian hypertrophy which occurs after surgical trauma was found to be due to an increase in the number of Graafian follicles and corpora lutea.Further experiment showed that, as judged by the weight of the ovaries, adrenalectomy reduces the ovarian reaction to injected PMS (10 i.u./day) in both adult and immature rats. Replacement therapy with DCA (1 mg/day) failed to re-establish the normal response in adults. Treatment with cortisone (1 mg/day) restored the normal reaction in both adult and immature adrenalectomized rats.Adrenalectomized adult rats responded to injected CG (10 i.u./day) as vigorously as their operated and unoperated litter-mates. On the other hand, immature adrenalectomized animals did not respond fully to CG. Treatment with cortisone again fully restored the normal reaction.A variety of studies suggests that the ovaries of adrenalectomized animals do not function normahy, and that their weight decreases [Parkes, 1945;Courrier, Badesse & Marois, 1953;Zuckerman, 1953]. The imphcation of these observations is (a) that fewer fohicles mature after the operation, or (6) that a smaller number luteinize. Either way it follows that less gonadotrophin is discharged by the pituitary, or that the sensitivity of the ovaries to gonadotrophins is decreased.The available evidence is insufficient to decide between these alternatives. Winter, Reiss & Bálint [1934] report that the ovaries of immature adrenalectomized rats treated with extracts of pregnancy urine do not luteinize. Payne [1951] made a complementary observation, in so far as he found that immature adrenalectomized animals do not react to a single injection of chorionic gonadotrophin with the typical ovarian hyperaemic reaction that is used as an index in pregnancy diagnosis. He also noted that the normal response is restored by replacement therapy with cortisone.On the other hand, Brolin & Lindbäck [1951] report that the ovaries of adult adrenal¬ ectomized animals respond normally both to pregnant mare serum and to chorionic gonadotrophin.In view of the fragmentary nature of these observations, it was decided to reinvestigate the problem, taking such precautions as, in the light of the work referred to above, seemed necessary to exclude non-specific effects and to assure the complete¬ ness of adrenalectomy. The first part of the present study thus deals with structural changes which occur in the ovaries of rats after adrenalectomy. The second is con¬ cerned with the effects of injected gonadotrophins.

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Section: Ovarian Changes After Adrenalectomy (Series I) Ovarian Weightsmentioning

confidence: 54%

The Sensitivity of Adrenalectomized Rats to Gonadotrophins

Mandl¹

1954

Journal of Endocrinology

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“…It is also interesting to note that a number of stressors are known to induce pseudopregnancy and lactational changes in the female rat (Swingle et al 1951;Nicoll et al 1961). It seems, therefore, that disruptions of reproductive function could be a non-adaptive change associated with a psychological stress response.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural Changes in the Adenohypophysis, Adrenal Gland Activity, and Desynchronization of the Oestrous Cycle following Unpredictable Stress in the Rat

Pollard¹,

Kd²

1977

Aust. Jnl. Of Bio. Sci.

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An ultrastructural study of the adenohypophysis, after exposure of female Wistar rats to a signalled unpredictable 5-and I5-day stress regimen, is described. Cellular activity of the adenohypophysis correlated well with the circulating levels of corticosterone. Intense secretory activity was observed in all tropic cell types at 5 and 15 days although the observed differences generally were greater in the 5-day stressed group. It was observed that the oestrous cycles of 40 and 100 % of the rats became desynchronized over the 5-and I5-day stress period respectively.

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“…The release of prolactin in response to stress in the rat has been well established (Swingle, Seay, Perlmutt, Collins, Barlow & Fedor, 1951;Neill, 1970;Ajika, Kalra, Fawcett, Krulich & McCann, 1972;Dunn, Arimura & Scheving, 1972), although it is not known whether such an effect occurs in the ferret.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ergot Alkaloids Upon Luteal Function in the Ferret

Blatchley¹,

Donovan²

1974

Journal of Endocrinology

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Since ergocornine is believed to block prolactin secretion in several species, the drug was given to pseudopregnant ferrets in an attempt to define the r\l =o^\l e of the hormone in the control of luteal function. The effects of ergocornine, and of the more potent analogue 2-bromo-\g=a\-ergocryptine, were followed by assay of the progestin content of the blood and histological examination of the ovaries. Ergocornine was given at the time of induction of pseudo\x=req-\ pregnancy by an injection of luteinizing hormone (day 0), on day 1, days 0 and 1, days 0, 2, 4 and 6, or day 7, and 2-bromo-\g=a\-ergocryptine on days 0, 1, 2 and 3, or 7, 8, 9 and 10. A lasting depression of plasma progestin content occurred after the injection of ergocornine on days 0 and 1, perhaps because of interference with the formation of the luteal bodies. Other injection r\l=e'\gimes had little effect on progestin secretion.

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An Experimental Study of Pseudopregnancy in Rat

Cited by 24 publications

References 0 publications

The Sensitivity of Adrenalectomized Rats to Gonadotrophins

The Sensitivity of Adrenalectomized Rats to Gonadotrophins

Ultrastructural Changes in the Adenohypophysis, Adrenal Gland Activity, and Desynchronization of the Oestrous Cycle following Unpredictable Stress in the Rat

Effect of Ergot Alkaloids Upon Luteal Function in the Ferret

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