Magnesium pemoline, a central nervous stimulant which may affect brain RNA production, produces a deficit in passive avoidance behavior. The main effect of the drug appears to be stimulation, with no effect on learning.
In order to investigate the effects of cingulate lesions on the development of frustrative emotionality, operated and normal rats (N -32) were given 42 runway trials with either 15-or 1-pellet rewards, followed by 36 trials during which all animals received 1 pellet. Cingulate lesions caused a significant (p < .01) reduction in the magnitude of the depression effect for start, run, and goal measures. It is suggested that lesions in the cingulate area result in a dissociation of emotional responses from ongoing instrumental behavior.
Magnesium pemoline, a central nervous stimulant implicated in brain RNA production, decreases both time and errors in the Hebb-Williams maze, a test of animal intelligence. The effect of the drug on errors is confounded with its effect on time, but seems to have a component independent of the latter effect.
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