Disruption of passive avoidance learning by magnesium pemoline

Gurowitz, Edward M.; Lubar, Joel F.; Ain, Brent R.; Gross, David A.

doi:10.3758/bf03330646

Cited by 22 publications

(9 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 (1) effect than for its having the effect of enhancing learning and memory. For example, recent reports show that MP produces increased motor activity (Boitano & Boitano, 1967) and a deficit in passive-avoidance learning, where animals are required to inhibit a response (Gurowitz, Lubar, Ain, & Gross, 1967). However, the picture at this point is confused by differences among the various reports in such variables as stock of Sand the type of task used to assess the effeet ofMP.…”

Section: Magnesium Pemoline: Different Effectsmentioning

confidence: 71%

Magnesium pemoline: Different effects with different subject stocks

Corson

1969

Psychon Sci

View full text Add to dashboard Cite

in an attempt to determine the effect of long-term administration of MP on performance of tasks of various levels of difficulty and which presumably require various levels of cognitive operation. We conducted one such study with Long-Evans rats and another with Sprague-Dawley rats. We found effects of MP, in both stocks, on performance in a shock-escape situation involving a pole-climbing response. However, there were no consistent effects, in either stock, on performance in other shock-motivated situations. Furthermore, the effects on the pole-climbing performance were different in the two stocks of SS. With the Long-Evans rats, MP inereased the number of responses made during the second day of learning and prolonged extinction, while with the Sprague-Dawley rats, MP decreased the number of responses on the first day of learning and had no effect on extinction. Since these studies had involved running the animals through aseries of shock-motivated tasks before they were trained in the pole-climbing apparatus, there was necessarily a confounding of variables such as length of injection period and interference and transfer relationships among the tasks used. The present study was done in order to determine the effects of MP on the performance of two stocks of Ss without the confounding effects which were present in the previous studies. For this purpose, naive Ss of both stocks were run only on the pole-climbing task.

show abstract

Section: Magnesium Pemoline: Different Effectsmentioning

confidence: 71%

Magnesium pemoline: Different effects with different subject stocks

Corson

1969

Psychon Sci

View full text Add to dashboard Cite

show abstract

“…Positive findings with avoidance studies (Plotnikoff, 1966;Beach & Kimble, 1967;Powell, Martin, & Kamano, 1967a, b;Filby, Szara, & Salzman, 1967;Frey & Polidora, 1967;Kulkarni, 1967;and Thompson & Knudson, 1968) have indicated that MP may facilitate performance although the results have not always been interpreted as demonstrating an effect upon learning or memory. Negative findings with MP in an avoidance task have been reported by Cyert, Moyer, & Chapman (1967), Chase & Rescorla (1968), and Gurowitz et al (1967).…”

mentioning

confidence: 87%

The effects of magnesium pemoline upon repeated acquisition and extinction of a bar press response

Adams¹,

Crawford²,

Lee³

1969

Psychon Sci

View full text Add to dashboard Cite

“…The interpretation of its effects has centered around the distinction between performance and learning. Other studies have failed to demonstrate any effect of magnesium pemoline on behavior (Chase & Rescorla, 1968;Gurowitz et al, 1967;McCarroll & Korbel, 1968;Cyert et al, 1967). The conflicting results are not at all surprising when one finds variation in these studies in terms of species of animals used, drug dosages, administration route of the drug, training procedures, apparatuses, dependent variables, criterion of learning, and such conditioning parameters as shock intensity, scrambled vs non scrambled shock, CS, UCS and intertrial intervals, and type of CS employed.…”

mentioning

confidence: 99%

Effect of magnesium pemoline on avoidance conditioning and intertrial activity in two strains of inbred mice

1969

View full text Add to dashboard Cite

Magnesium pemoline was found to have a differential effect on behavior depending upon genotype. The drug resulted in increased activity and reduced avoidance scores for the fast-conditioning C3H strain of mice, whereas it significantly increased avoidance scores and activity for the slow-conditioning ST/bl strain. The effect of magnesium pemoline on behavior is discussed in terms of an inverted-U relationship between reactivity and learning.

show abstract

Disruption of passive avoidance learning by magnesium pemoline

Abstract: Magnesium pemoline, a central nervous stimulant which may affect brain RNA production, produces a deficit in passive avoidance behavior. The main effect of the drug appears to be stimulation, with no effect on learning.

Cited by 22 publications

References 9 publications

Magnesium pemoline: Different effects with different subject stocks

Magnesium pemoline: Different effects with different subject stocks

The effects of magnesium pemoline upon repeated acquisition and extinction of a bar press response

Effect of magnesium pemoline on avoidance conditioning and intertrial activity in two strains of inbred mice

Contact Info

Product

Resources

About