INTRODUCTION: Cognitive impairment is frequent in multiple sclerosis and predominantly affects visuospatial abilities, memory, attention, and executive functions. Because of the specific cognitive profile, different from that in Alzheimer's disease and other frequent disorders presenting with dementia, specific neuropsychological instruments need to be used in multiple sclerosis. The aim of the present study is to assess the applicability of the Rey-Osterrieth complex figure test (ROCFT) for assessing cognitive impairment in patients with multiple sclerosis in comparison with a control group. MATERIAL AND METHODS: One hundred and two individuals, 70 patients with MS and 32 healthy control subjects were assessed using ROCFT. A standardized system for assessment by points and percentages was used. The results from both groups were compared statistically using independent samples t-test. RESULTS: On the copying task, the differences between patients and controls reached statistical significance, p<0.05 for the raw score, and p<0.001 after results were grouped by percentiles. On the drawing by memory task the differences between the two groups also showed statistical significance, p<0.01. CONCLUSION: ROCFT shows statistically significant differences between patients with multiple sclerosis and healthy subjects. Highest levels of significance were observed for copying, scored by percentiles, and for drawing by memory. The application of ROCFT can provide valuable information about cognitive dysfunction in multiple sclerosis.
SummaryThe aim of the investigation was to analyze the correlation between myocardial infarction and ischemic heart disease, on the one hand, and acute ischemic stroke (AIS), on the other hand. We studied 258 AIS patients (mean age 70.9±7.22 years, range 49-92 years) hospitalized in 2007-2013 in the First Clinic of Neurology, St. Marina University Hospital of Varna. The diagnosis of acute ischemic stroke was confirmed by Doppler sonography and computed tomography of the cerebral circulation. Data were statistically processed by variation and correlation analysis. Our results proved a relatively strong correlation between effort angina pectoris and ischemic heart disease (Pearson's coefficient: r=0.643) as well as a weak correlation between ischemic heart disease and myocardial infarction (Pearson's coefficient: r=0.243) among acute ischemic stroke patients. The well-known risk factors for these cardiovascular diseases such as obesity, tobacco smoking, low physical activity and alcohol abuse were common among the patients with acute ischemic stroke, too. In conclusion, both myocardial infarction and ischemic heart disease are strongly associated with the development of acute ischemic stroke. Such patients require strict and regular control by general practitioners. They should observe an appropriate diet and adhere to a healthy life-style.
INTRODUCTION:There is rising evidence of the role of hyperlipidemia and dyslipidemia in the development of acute ischemic stroke (AIS). There is a considerable risk for AIS in adult individuals with these abnormalities. Our purpose was to reveal the incidence rate of the disorders of lipid metabolism in adult AIS patients.
INTRODUCTION:There is rising evidence of the role of hyperglycemia, hyperlipidemia and dyslipidemia in the etiopathogenesis of acute ischemic stroke (AIS). There is a considerable risk for AIS in adult individuals in advanced and senile age with these abnormalities. Our purpose was to reveal the incidence rate of the disorders of glucose and lipid metabolism in adult patients with AIS.
INTRODUCTION: Effective and timely prevention of acute ischemic stroke (AIS) is characterized by a rising socio-medical importance as this is the most common cerebrovascular disease worldwide and in Bulgaria as well. Our purpose was to reveal the incidence rate of the disorders of glucose metabolism in AIS development among adult patients. MATERIAL AND METHODS: We examined 129 male and 129 female patients with AIS at a mean age of 70.59±7.22 years hospitalized in the First Clinic of Neurology, St. Marina University Hospital of Varna in 2007-2013. Blood glucose concentrations at admission were examined. Statistical data processing was performed by variation (ANOVA as t-criterion was considered significant if p<0.05) and correlation (Pearson's coefficient) analyses. RESULTS: Mean fasting blood glucose levels were most commonly elevated and total ones were higher in males than in females except for the minimal value. The males with abnormally elevated blood glucose values present with higher mean and maximal values than the females. The number and relative share of the patients with increased blood glucose values at admission considerably prevailed. The difference between the number of the males with increased values and that of those with normal values was statistically significant (t=3.33; p<0.01). There was moderate correlation between the level of blood glucose and the preceding diabetes mellitus (r=0.431) and a strong one between this level and the newly-diagnosed diabetes mellitus (r=0.733) among our AIS patients. CONCLUSION: The regular control of blood glucose by the general practitioners and the promotion of the healthy lifestyle in cardiovascular disease patients could successfully prevent AIS in Bulgaria.
Кардиоваскуларната автономна дисфункция след инсулт има голямо клинично значение, тъй като влошава прогнозата и може до доведе до внезапна ритъмна смърт. Повишената симпатикова активност след инсулт може да доведе до абнормности в ЕКГ, сърдечни аритмии и некроза на миокарда. Наред с проявите на метаболитна ацидоза се повишават плазмените нива на редица биохимични маркери -норепинефрин, епинефрин и допамин; сърдечни ензими и маркери: креатин киназата и креатин киназата -МВ, тропонин I и B-тип натриуретичен пептид. Повишените нива на катехоламините са най-ясно изразени при пациенти с лезии в територията на дясна средна мозъчна артерия и са значимо по-високи по време на острата фаза на инсулт.
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