Interleukin 8: Changes in Paroxysmal Atrial Fibrillation

Negreva, Мariya; Georgiev, Svetoslav; Vitlianova, Katerina; Arabadzhieva, Daniela

doi:10.9734/bjmmr/2015/20238

Cited by 2 publications

(4 citation statements)

References 20 publications

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“…Our results are in line with findings from previous studies, which reported increased plasma levels of inflammatory cytokines in patients with AF ( 22 – 25 ). Inflammatory mechanisms have been associated with the pathogenesis and maintenance of AF, as well as in the AF-related thrombogenesis ( 19 ).…”

Section: Discussionsupporting

confidence: 93%

“…In a previous study, this cytokine was considered an independent predictive factor for recurrence of AF, once elevated plasma levels of IL-2 were detected in patients with AF who presented recurrence of AF after catheter ablation therapy, in comparison with control subjects in sinus rhythm ( 28 ). IL-4, in turn, is a cytokine expressed and produced by activated T-helper type 2 (Th2) lymphocytes and basophils, which has regulatory actions on allergic responses, as well as anti-tumor and anti-inflammatory effects ( 22 ). This mediator was considered as a predictive marker of the incidence of AF since high levels of this cytokine were found in patients admitted to the hospital with AF in comparison with controls ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

“…IL-4, in turn, is a cytokine expressed and produced by activated T-helper type 2 (Th2) lymphocytes and basophils, which has regulatory actions on allergic responses, as well as anti-tumor and anti-inflammatory effects ( 22 ). This mediator was considered as a predictive marker of the incidence of AF since high levels of this cytokine were found in patients admitted to the hospital with AF in comparison with controls ( 22 ). IL-10, an anti-inflammatory cytokine produced by monocytes and Th2 lymphocytes, and IFN-γ, an immunomodulatory cytokine produced by NK cells and Th1 lymphocytes, were associated with the development of AF after coronary artery bypass grafting ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Inflammatory Mediators in Patients With Atrial Fibrillation Using Warfarin or Rivaroxaban

Martins

Duarte

Vieira

et al. 2020

Front. Cardiovasc. Med.

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Background: Atrial fibrillation (AF) is the most common arrhythmia associated with high risk of venous thromboembolism. Inflammatory mechanisms may be involved in the pathophysiology of AF and in the AF-related thrombogenesis, and patients with AF might benefit from the use of anticoagulants with anti-inflammatory properties. However, the evidence is still scarce, and it points out the need of trials seeking to investigate the levels of inflammatory mediators in patients with AF under different anticoagulant therapies. Therefore, this study was designed to define whether patients with AF treated either with an activated coagulation factor X (FXa) inhibitor (rivaroxaban) or with a vitamin K inhibitor (warfarin) present changes in peripheral levels of inflammatory mediators, mainly cytokines and chemokines. Methods: A total of 127 subjects were included in this study, divided into three groups: patients with non-valvular atrial fibrillation (NVAF) using warfarin (N = 42), patients with NVAF using rivaroxaban (N = 29), and controls (N = 56). Plasma levels of inflammatory mediators were quantified by immunoassays. Results: Patients with AF (both warfarin and rivaroxaban groups) presented increased levels of inflammatory cytokines in comparison with controls. The use of rivaroxaban was associated with decreased levels of inflammatory cytokines in comparison with warfarin. On the other hand, patients with AF using rivaroxaban presented increased levels of the chemokines (MCP-1 in comparison with warfarin users; MIG and IP-10 in comparison with controls). Conclusions: AF is associated with an inflammatory profile that was less pronounced in patients on rivaroxaban in comparison with warfarin users. Further studies are necessary to assess the clinical implications of our results and whether patients with AF would benefit from rivaroxaban anti-inflammatory effects.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Inflammatory Mediators in Patients With Atrial Fibrillation Using Warfarin or Rivaroxaban

Martins

Duarte

Vieira

et al. 2020

Front. Cardiovasc. Med.

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“…Applied by us logistic model, except that identify significant factors gives the possibility to calculate the probability that a certain amount of factors are expected to occur complication. Precisely because of the possibility to predict the probability of complication logistics model is applied in a variety of context, including cohort and case-control studies, problems in differential diagnosis and prediction and in the analysis of survey data [8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Predictors for the Choledocholithiasis. Retrospective Study for Bulgarian Patients

Dineva¹,

Prodanova²,

Getsov³

et al. 2017

IOSR JDMS

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The presence of a periampullary duodenal diverticulum (PDD) is often observed during upper digestive tract barium meal studies and endoscopic retrograde cholangiopancreatography (ERCP). The impact of periampullary duodenal diverticulum for the formation of gallstones in the bile duct (choledocholithiasis) is widely accepted. In this study it using logistic regression modeling the appearance of choledocholithiasis depending periampullary duodenal diverticulum, to confirm the connection between them. The resulting model allows evaluation of the estimated probability of occurrence of this complication. The model is based on the 1719 recording of endoscopic retrograde cholangiopancreatography performed in the

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Interleukin 8: Changes in Paroxysmal Atrial Fibrillation

Cited by 2 publications

References 20 publications

Comparison of Inflammatory Mediators in Patients With Atrial Fibrillation Using Warfarin or Rivaroxaban

Comparison of Inflammatory Mediators in Patients With Atrial Fibrillation Using Warfarin or Rivaroxaban

Predictors for the Choledocholithiasis. Retrospective Study for Bulgarian Patients

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