Serum lipid anomalies in adult patients with acute ischemic stroke

Arabadzhieva, Daniela; Slavov, Zdravko Dimitrov; Kaprelyan, Ara

doi:10.14748/ssm.v47i2.1056

Cited by 1 publication

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References 18 publications

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“…In the same mutant mouse model studied here, as it is also considered a model of ischemic stroke [ 29 ], the occurrence of spreading depolarizations surrounding the infarcted cortical area [ 30 ] were associated with changes in the lipid profile in brain tissue [ 31 ]. Moreover, for both mice [ 32 ] and patients following stroke [ 33 ] lipid changes were observed in plasma. In a rat model for temporal lobe epilepsy, lipid concentrations measured both in the hippocampus and plasma revealed upregulation of DHA [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Changes in Plasma Lipid Levels Following Cortical Spreading Depolarization in a Transgenic Mouse Model of Familial Hemiplegic Migraine

et al. 2022

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Metabolite levels in peripheral body fluids can correlate with attack features in migraine patients, which underscores the potential of plasma metabolites as possible disease biomarkers. Migraine headache can be preceded by an aura that is caused by cortical spreading depolarization (CSD), a transient wave of neuroglial depolarization. We previously identified plasma amino acid changes after CSD in familial hemiplegic migraine type 1 (FHM1) mutant mice that exhibit increased neuronal excitability and various migraine-related features. Here, we aimed to uncover lipid metabolic pathways affected by CSD, guided by findings on the involvement of lipids in hemiplegic migraine pathophysiology. Using targeted lipidomic analysis, we studied plasma lipid metabolite levels at different time points after CSD in wild-type and FHM1 mutant mice. Following CSD, the most prominent plasma lipid change concerned a transient increase in PGD2, which lasted longer in mutant mice. In wild-type mice only, levels of anti-inflammatory lipid mediators DPAn-3, EPA, ALA, and DHA were elevated 24 h following CSD compared to Sham-treated animals. Given the role of PGs and neuroinflammation in migraine pathophysiology, our findings underscore the potential of monitoring peripheral changes in lipids to gain insight in central brain mechanisms.

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