Cerebrovascular diseases are a global medical and social issue because of the high morbidity, mortality and disability they cause. WHO announces 15 Mio ischemic stroke occurrences per year globally, with 5 Mio associated deaths and 5 Mio left permanently disabled. Thrombolysis (TL) with tissue plasminogen activator (rt-PA) is currently an approved differentiated pharmaco-therapeutic treatment of ischemic stroke (IS) in its acute phase. There is irrefutable evidence of better health results and efficient clinical management of ischemic strokes within an integrated therapeutic approach as a key factor for improving the functional outcome in stroke patients. Quality is one of the most widely discussed issues in the theory and practice of disease management. The rigid compliance with the standards for treatment of ischemic strokes is an indicator of high quality patient management.
Хипергликемията по време на остър коронарен синдром (ОКС) при пациенти без известен диабет е честа и се счита, че е "стресова". От друга страна тя може да е първата индикация за предходно неразпознато гликемично нарушение. Цел: Да се потърси връзка между кръвната глюкоза (КГ) при спешна хоспитализация поради ОКС и глюкозните показатели в хода на орален глюкозотолерантен тест (ОГТТ). Материали и методи: При 96 лица с проведена KA±PCI и без анамнеза за гликемични нарушения се приложи стандартен ОГТТ между 3 и-10 и ден след дехоспитализацията. Глюкозният статус се класифицира според критериите на СЗО-2006 г., за плазмена глюкоза на гладно (ПГГ) и плазмена глюкоза на 2 ри час (2-ч-ПГ). Анализирана е КГ по време на спешен прием при 39 пациенти с ОКС. Резултати: Установихме нарушен глюкозен метаболизъм при 64.58%, а хипергликемия на 2 ри час (≥7,8 ммол/л)-при 52.1% от изследваните след проведения ОГТТ. Средната КГ при спешно приемане на лицата с новооткрит тип 2 заха-ABSTRACT Introduction: Hyperglycemia during acute coronary syndrome (ACS) in patients without known diabetes is common and is considered "stress hyperglycemia". On the other hand, it could be the first indication for previous unrecognized glycemic abnormality. Aim: To search for correlation between blood glucose (BG) at acute admission due to ACS and glycemic parameters during oral glucose tolerance test (OGTT). Materials and methods: A standard OGTT 3-10 days after hospital discharge was applied in 96 patients without history of glucose abnormalities who underwent coronary angiography (CA) ± percutaneous coronary intervention (PCI). Glucose tolerance was defined according to WHO-2006 criteria for fasting plasma glucose (FPG) and 2-hour-plasma glucose (2-h-PG). The BG at acute admission in 39 ACS patients was analyzed. Results: We found impaired glucose metabolism in 64.58% and 2-hour-hyperglycemia (≥7,8 mmol/L) in 52,1% of study participants after the OGTT. Mean BG at acute admission in subjects with newly-diagnosed type 2 diabetes mellitus (nT2DM) was 9,55±1,93 mmol/L.
Едни от най-важните автономни нарушения след мозъчен инсулт са кардиоваскуларните и терморегулаторните усложнения. Асиметрията в кожната температура и потната секреция отразяват вазомоторната автономна дисрегулация и повлиява качеството на живот на пациентите с инсулт. По-голяма част от болните описват "чувство на студенина" в паретичните крайници. При хемисферен инсулт често се наблюдава хиперхидроза на паретичната страна на тялото, най-силно изразено в острата фаза на инсулт.
Diabetes mellitus (DM) is a major risk factor for stroke, which is associated with unfavorable outcome after acute ischemic stroke (AIS) and disability. The potential harmful effect of DM, and the role and importance of blood glucose (BG) at admission are currently unclear for a clinical outcome after АIS. The aim of this study is to look for correlations between the presence of DM and the initial level of BG, and the clinical outcome after an intravenous thrombolysis (IVT) in patients with acute AIS. MATERIALS AND METHODS: CONCLUSION:Patients with DM have significantly higher mortality and lack of favorable functional outcome at the third month compared to those without DM, which cannot be explained by the presence of ICH. The initial HG is not significantly associated with an unfavorable clinical outcome, but it quickly identifies patients with an increased risk of such an outcome in whom the blood sugar levels should be closely monitored.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.