Impact of diabetes mellitus and admission hyperglycemia on outcomes after intravenous thrombolysis in acute ischemic stroke patients

Abstract

Diabetes mellitus (DM) is a major risk factor for stroke, which is associated with unfavorable outcome after acute ischemic stroke (AIS) and disability. The potential harmful effect of DM, and the role and importance of blood glucose (BG) at admission are currently unclear for a clinical outcome after АIS. The aim of this study is to look for correlations between the presence of DM and the initial level of BG, and the clinical outcome after an intravenous thrombolysis (IVT) in patients with acute AIS. MATERIALS AND METHODS: CONCLUSION:Patients with DM have significantly higher mortality and lack of favorable functional outcome at the third month compared to those without DM, which cannot be explained by the presence of ICH. The initial HG is not significantly associated with an unfavorable clinical outcome, but it quickly identifies patients with an increased risk of such an outcome in whom the blood sugar levels should be closely monitored.