Idiopathic hypertrophy of the masseter muscle is a rare disorder of unknown cause. Some authors associate it with the habit of chewing gum, temporo-mandibular joint disorder, congenital and functional hypertrophies, and emotional disorders (stress and nervousness). Most patients complain of the cosmetic change caused by facial asymmetry, also called square face, however, symptoms such as trismus, protrusion and bruxism may also occur. The goals of the present investigation were: to report a case of idiopathic masseter hypertrophy, describe its symptoms and treatment. The patient reported bilateral bulging in the region of the mandible angle, of slow and progressive evolution. He did not complain of pain or discomfort, however there was bilateral otalgia, nighttime trismus and stress. In his physical exam we noticed bilateral masseter hypertrophy without local inflammatory alterations. We indicated surgical treatment with an extraoral approach. Complementary tests are indicated when there is diagnostic doubts. Treatment varies from conservative to surgical, and the later depends on surgeon skill and experience.

RESUMOIntrodução: O mesocarpo de Orbignya phalerata tem sido usado em estudos experimentais procurando verificar sua ação pró-inflamatória. Objetivo: Analisar comparativamente as alterações histológicas proporcionadas pelo extrato aquoso do Babaçu nas feridas cutâneas. Métodos: Sessenta ratos da linhagem Wistar, adultos, machos, foram utilizados. O procedimento experimental constituiu-se em uma incisão circular de 2cm de diâmetro na pele com punch metálico. Após este procedimento comum a todos, os animais foram distribuídos aleatoriamente em dois grupos contendo 30 animais cada. No grupo controle não foi utilizada a substância pesquisada e sim, solução fisiológica (Cloreto de sódio a 0,9%). No grupo experimento utilizou-se solução aquosa de Orbignya phalerata em uso tópico. Os animais foram acompanhados e mortos em sete, 14 e 21 dias. Foi feita análise histológica comparativa entre os grupos. Resultados: Observou-se diferença significativa a favor da cicatrização do grupo experimento em relação ao grupo controle nos 7º e 14º dias, no que diz respeito à reepitelização. Conclusão: O uso tópico do mesocarpo de Orbignya phalerata (Babassu) contribuiu positivamente para a cicatrização das feridas cutâneas em ratos com a dosagem de 25mg/ml. Descritores: Orbignya phalerata. Cicatrização de Feridas. Pele. Ratos. ABSTRACT Introduction:The mesocarp of Babassu (Orbignya phalerata) has been used in experimental studies trying to check its pro-inflammatory effect. Purpose: To analyse comparatively the histological changes made by the water extract of Babassu in skin surgical wounds. Methods: Sixty Wistar adults male rats were used. The experimental procedure was a circle skin incision of 2 cm in diameter made with a metal punch. After this procedure done in all animals, they were randomized in two groups of 30. In the control group, the phytotherapic agent wasn't used but saline solutin. In the experimental group, the water extract of Orbignya phalerata was used in the cut sites. All animals were followed and killed after seven, 14 and 21 days. Comparative histological analysis was made among the groups. Results: In the microscopic view, a significant reepitelization effect on the healing process of the experimental group in relation to the control group in the 7 th and 14 th days, was recognized. Conclusion: The use of the mesocarp of Orbignya phalerata in skin surgical wounds contributed positively in the healing process in rats. Key words: Orbignya phalerata. Wound Healing. Skin. Rats. IntroduçãoA capacidade de reparação tecidual é fenômeno observado nos seres vivos e de grande importância para sua sobrevivência quando ocorrem lesões acidentais ou cirúrgicas.A cicatrização dos tecidos e órgãos constitui-se em um processo biológico complexo essencial para manter a integridade do organismo, mas que ainda não está totalmente esclarecido.Ao longo dos séculos, procurou-se verificar a ação de substâncias químicas e/ou de procedimentos que pudessem agilizar o processo, quer na ferida limpa, quer na contaminada ou infectada 1 . C...

several adjuvant therapies to surgery have been used to modulate the healing process of vocal folds, including topic mitomycin (MTC). Aim: to evaluate the effect of topical MTC in the healing process of vocal folds 30 days after the exeresis of a mucosal fragment with CO 2 laser in a swine model (control group without mitomycin and study group with topical MTC), with collagen deposition measurement. Study type: prospective experimental in swine. Methods: two groups of 6 swine each were subjected to exeresis of a mucosal fragment of the vocal fold with CO 2 laser. Immediately after the procedure MTC was applied topically for three minutes on the study group. Thirty days later the animals were slaughtered and samples of the vocal folds were collected for histological analysis, with the purpose of quantifying collagen deposition by Picrosirius Red stain. Results: the average area of total collagen in the vocal folds in the control group was 2.648,03 µm2, whereas in the study group it was 2.200,30 µm2 (p = 0.0043). Conclusion: topical application of MTC after the exeresis of a mucous fragment of vocal fold with CO 2 laser in swine significantly decreased total collagen deposition.

topical application of MTC after the exeresis of a mucous fragment of vocal fold with CO2 laser in swine significantly decreased total collagen deposition.

A hipertrofia idiopática do músculo masseter (HIM) é uma patologia pouco freqüente e de causa desconhecida. Alguns autores correlacionam tal condição com hábitos de mascar gomas, disfunção da articulação temporomandibular (ATM), hipertrofias congênitas e funcionais, e distúrbios emocionais (nervosismo e ansiedade). A maioria dos pacientes queixa-se da alteração estética decorrente da assimetria facial, também chamada "face quadrada", no entanto, sintomas como trismo, protrusão e bruxismo também podem ocorrer. Os objetivos deste estudo foram: relatar um caso de HIM e descrever a sintomatologia e o tratamento realizado. O paciente relatava aumento bilateral na região do ângulo da mandíbula de evolução lenta e progressiva. Negava dor ou desconforto, porém se queixava de otalgia bilateral, trismo noturno e ansiedade. Ao exame físico, observou-se hipertrofia bilateral de masseter sem alterações inflamatórias no local. Foi indicado tratamento cirúrgico com abordagem extra-oral. Exames complementares são indicados na dúvida diagnóstica. A conduta terapêutica varia de conservadora a cirúrgica, sendo que esta depende principalmente da experiência e da habilidade do cirurgião.

Efeito da mitomicina-C tópica sobre os depósitos de colágeno total na Efeito da mitomicina-C tópica sobre os depósitos de colágeno total na Efeito da mitomicina-C tópica sobre os depósitos de colágeno total na Efeito da mitomicina-C tópica sobre os depósitos de colágeno total na Efeito da mitomicina-C tópica sobre os depósitos de colágeno total na submucosa das pregas vocais íntegras de suínos submucosa das pregas vocais íntegras de suínos submucosa das pregas vocais íntegras de suínos submucosa das pregas vocais íntegras de suínos submucosa das pregas vocais íntegras de suínos MARCELO The animals were divided into three groups according to the composition of the topical solution to be applied to the vocal folds: 0.9% saline solution (control group); 4 mg/ml mitomycin-C (group 1) and 8 mg/ml mitomycin-C (group 2). Thirty days after the application, all animals were sacrificed, their vocal folds were collected and stained by the picrosirius red technique, and submucosal collagen deposition areas were estimated by the Image Pro Plus 4.5 ® software. Mann-Whitney test was used to compare differences between parameters of each group. Results Results ResultsResults Results: The means of the areas of submucosal collagen deposits on vocal folds were 3110.44 square micrometers (µm 2 ), 3115.98 µm 2 and 3105.78 µm 2 for groups control, 1 and 2, respectively. There were no statistical differences across the three groups (p>0.05). Conclusion Conclusion Conclusion Conclusion Conclusion: Mitomycin-C topically applied to intact vocal folds of swine did not alter submucosal collagen deposition.

Summary Introduction: Chronic obstructive pulmonary disease is characterized by progressive and partially reversible obstruction of pulmonary airflow. Aim: To characterize swallowing in patients with chronic obstructive pulmonary disease and correlate the findings with the degree chronic obstructive pulmonary disease, heart and respiratory rate, oxygen saturation, and smoking. Method: We conducted a prospective cohort study of 19 patients (12 men and 7 women; age range, 50–85 years) with confirmed medical diagnosis of chronic obstructive pulmonary disease. This study was performed in 2 stages (clinical evaluation and functional assessment using nasolaryngofibroscopy) on the same day. During both stages, vital signs were checked by medical personnel. Results: Clinical evaluation of swallowing in all patients showed the clinical signs of cough. The findings of nasolaryngofibroscopy highlighted subsequent intraoral escape in 5 patients (26.5%). No patient had tracheal aspiration. There was no association of subsequent intraoral escape with degree of chronic obstructive pulmonary disease, heart and respiratory rate, oxygen saturation, or smoking. Conclusion: In patients with chronic obstructive pulmonary disease, there was a prevalence of oral dysphagia upon swallowing and nasolaryngofibroscopy highlighted the finding of subsequent intraoral escape. There was no correlation between intraoral escape and the degree of chronic obstructive pulmonary disease, heart and respiratory rate, oxygen saturation, or smoking.

Introduction Over the years the immune system suffers many morphologic and functional alterations, which result in a peak of function in puberty and a gradual decrease in the elderly. Aim Treat patients 55 years or older with allergic rhinitis with immunotherapy and then analyze the response to allergens. Materials and Methods From June 2009 to July 2010, 104 charts of patients 55 years or older with allergic complaints were evaluated. The patients were selected by anamnesis, physical examination, and otorhinolaryngologic exam. The patients had cutaneous test for mites before and after 1 year of sublingual specific immunotherapy. The cutaneous response was classified as negative (absent), light, moderate, or severe. Results Before vaccination, 42 (40.4%) patients were classified as having a severe form of allergy and 62 (59.6%) as having a moderate allergy. After the specific therapy, 40 (38.4%) patients were classified as negative (absent), 37 (35.6%) as light, 19 (18.3%) as moderate, and 8 (7.7%) as severe responses. Conclusion Immunotherapy, a desensitization technique, is indicated in cases which patients cannot avoid the exposure to allergens and in situations where pharmacologic therapy is not ideal. Specific immunotherapy to treat the allergic rhinitis in elderly patients was efficient and had no collateral effects, and in addition to the clinical benefit, improvement in the cutaneous test could also be observed.