Efeito da mitomicina-C tópica sobre os depósitos de colágeno total na Efeito da mitomicina-C tópica sobre os depósitos de colágeno total na Efeito da mitomicina-C tópica sobre os depósitos de colágeno total na Efeito da mitomicina-C tópica sobre os depósitos de colágeno total na Efeito da mitomicina-C tópica sobre os depósitos de colágeno total na submucosa das pregas vocais íntegras de suínos submucosa das pregas vocais íntegras de suínos submucosa das pregas vocais íntegras de suínos submucosa das pregas vocais íntegras de suínos submucosa das pregas vocais íntegras de suínos MARCELO The animals were divided into three groups according to the composition of the topical solution to be applied to the vocal folds: 0.9% saline solution (control group); 4 mg/ml mitomycin-C (group 1) and 8 mg/ml mitomycin-C (group 2). Thirty days after the application, all animals were sacrificed, their vocal folds were collected and stained by the picrosirius red technique, and submucosal collagen deposition areas were estimated by the Image Pro Plus 4.5 ® software. Mann-Whitney test was used to compare differences between parameters of each group. Results
Results ResultsResults Results: The means of the areas of submucosal collagen deposits on vocal folds were 3110.44 square micrometers (µm 2 ), 3115.98 µm 2 and 3105.78 µm 2 for groups control, 1 and 2, respectively. There were no statistical differences across the three groups (p>0.05). Conclusion Conclusion Conclusion Conclusion Conclusion: Mitomycin-C topically applied to intact vocal folds of swine did not alter submucosal collagen deposition.
Introduction The endoscopic access has reduced the morbidity associated with external approaches in diseases of the maxillary sinus. A reversible endoscopic medial maxillectomy (REMM) is presented as an alternative for treatment of benign maxillary diseases.
Objective To describe the REMM technique and report four cases of patients with benign maxillary sinus conditions treated through this approach.
Methods The present study was divided into two parts: anatomical and case series. Two cadaveric dissections confirmed the feasibility of the REMM approach. The same technique was performed on four consecutive patients with benign maxillary sinus disease.
Results The cadaveric dissections confirmed wide exposure to the maxillary cavity, preserving the anatomy of the maxillary sinus. In the patient series, one patient presented with an antrochoanal polyp, one had a silent sinus syndrome, one had a chronic maxillary sinusitis secondary to a gunshot, and the last one had an inverted papilloma in the maxillary sinus. In all of the cases, the REMM approach provided excellent access and adequate resection, as well as preservation of the inferior turbinate, nasolacrimal duct, and lateral wall of the nose (including its osteomucosal component). Finally, all of the patients had an uneventful postoperative course.
Conclusion The REMM technique is an excellent surgical approach to benign conditions of the maxillary sinus. It has few limitations and appears to be associated with less morbidity than conventional techniques.
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