Objective:to evaluate the quality of life of adult patients with hematological cancer comparing Hematopoietic Stem Cell Transplantation modalities during the first year of treatment. Method:this is an observational and longitudinal research with 55 participants. Data collection was performed in six steps: before transplantation, pancytopenia, before hospital discharge, after 100, 180 and 360 days, in a reference hospital in Brazil for this treatment. The international instruments Quality of Life Questionnaire - Core 30 and Functional Assessment Cancer Therapy - Bone Marrow Transplantation were validated and translated into Portuguese (Brazil). Results:the mean age of participants was 36 years, 65% (n = 36) had leukemia diagnosis and 71% (n = 39) had undergone allogenic transplantation. In the Quality of Life Questionnarie - Core30 instrument, the pain symptom was significant between the first and second stages, and loss of appetite between the third and fourth stages, both in the allogenic group. In the Functional Assessment Cancer Therapy - Bone Marrow Transplantation, the functional well-being domain was significant between the third and fourth stages, also in the allogenic group. Conclusions:although the aggressiveness of treatment affects quality of life, patients consider it satisfactory after the first year. There are few significant differences between autologous and allogenic patients, and both groups have recovered in the course of the process.

ResumoEnquadramento: O constructo religiosidade/espiritualidade e apoio social sugere melhoria na qualidade de vida nos doentes com cancro avançado em terapêutica paliativa ou cuidado paliativo. Objetivo: Verificar se as pessoas com cancro avançado que estão a receber terapêutica paliativa e/ou cuidado paliativo, utilizam a religiosidade/espiritualidade e apoio social para o enfrentamento da doença, e comparar o seu uso na melhoria da qualidade de vida. Metodologia: Estudo observacional, transversal e analítico, realizado num hospital no sul do Brasil, de janeiro a julho de 2018. Dados recolhidos através de um questionário sociodemográfico/clínico e do Quality of Life Questionnaire-Core 15-Palliative. O teste não paramétrico de Mann Whitney foi utilizado para análise comparativa. Resultados: Participaram 107 doentes na terapêutica paliativa e 19 no cuidado paliativo. O uso da religiosidade/ espiritualidade e apoio social foi unanimemente utilizado. A presença de um familiar como cuidador principal teve significância (p = 0,014), predizendo melhor qualidade de vida. Conclusão: Cabe ao enfermeiro promover o cuidado humano e viabilizar o uso do constructo religioso/espiritual e social, em especial a presença do cuidador familiar, para melhorar a qualidade de vida Abstract Background: The religion/spirituality and social support may improve the quality of life of patients with advanced cancer receiving palliative therapy or palliative care. Objective: To determine if patients with advanced cancer receiving palliative therapy and/or palliative care use religion/spirituality and social support to cope with the disease, and assess if these aspects improve their quality of life. Methodology: Observational, cross-sectional, and analytical study conducted in a hospital in southern Brazil from January to July 2018. A sociodemographic/clinical questionnaire and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire--Core 15 Palliative Care were used. The nonparametric Mann-Whitney test was used for comparative analysis. Results: A total of 107 patients receiving palliative therapy and 19 patients receiving palliative care participated in this study. Religion/spirituality and social support were unanimously used. The presence of a family member as the main caregiver was significant (p = 0.014), predicting a better quality of life. Conclusion: Nurses are responsible for promoting humanized care and the use of religion/spirituality and social support, namely the presence of family caregivers, with a view to improving the quality of life of patients with advanced cancer.

Objective To reflect on the understanding of financial toxicity, as an adverse event of cancer diagnosis and treatment, and its implications on the quality of life of these patients. Method Reflexive study, based on the international literature about the concept of financial toxicity and its relationship with quality of life. Results Financial toxicity is related to the financial difficulties associated with cancer and its treatment, which occur in the lives of patients and family members. Its consequences include: possible worsening of the clinical symptoms, indebtedness, loss of professional opportunities, changes in family habits and decline in quality of life. Final considerations Measures to minimize financial toxicity should also be a concern of the state and be part of the therapeutic itinerary of cancer patients. Dialogue can become an essential tool for the health team to clarify the therapeutic options and their costs. This attitude shows respect and preserves the patient’s autonomy, which can minimize the feeling of helplessness in the face of the disease.

Objective: to evaluate the quality of life of adult patients with hematologic cancers undergoing hematopoietic stem cell transplantation in the first six months and comparing the transplant modalities.Method: an observational longitudinal study with 55 participants followed during pre-transplantation, after 100 days, and after 180 days in a reference teaching hospital for this treatment in Brazil. Two international instruments were used for the evaluation, both validated and translated into Portuguese (Brazil): The Quality of Life Questionnaire-Core 30 and the Functional Assessment Cancer Therapy-Bone Marrow Transplantation. Results:The results showed that the average age of the participants was 36 years old; 65% (n=36) had a diagnosis of leukemia, and 71% (n=39) underwent allogeneic transplantation. Regarding the Quality of Life Questionnaire-Core 30 instrument, social function and fatigue were significant results, while the functional well-being and treatment outcome evaluation index for the Functional Assessment Cancer Therapy-Bone Marrow Transplantation questionnaire had significant domains between the first and the second stage.Conclusions: despite transplantation being a complex and aggressive treatment, it can be noticed that patients generally perceive their quality of life as satisfactory throughout the therapeutic process. The findings of the study show that a significant portion (69% of patients) recover their quality of life after the first six months of treatment. DESCRIPTORS: QUALIDADE DE VIDA NOS PRIMEIROS SEIS MESES PÓS-TRANSPLANTE DE CÉLULAS-TRONCO HEMATOPOÉTICAS CALIDAD DE VIDA EN LOS PRIMEROS SEIS MESES POST-TRANSPLANTES DE CÉLULAS-TRONCO HEMATOPOÉTICAS RESUMENObjetivo: evaluar la calidad de vida de los pacientes adultos con cáncer hematológico sometidos al transplante de células madre hematopoyéticas en los primeros seis meses y comparar entre las modalidades de trasplante.Método: estudio observacional, longitudinal, con 55 participantes, acompañados en las etapas pre-trasplante, después de 100 días y después de 180 días, en un hospital de enseñanza, referencia en Brasil para este tratamiento. Para la evaluación se utilizaron dos instrumentos internacionales, ambos validados y traducidos a la lengua portuguesa (

Objective: To assess the domains of quality of life related to hematologic cancer patient health in the first three years from autologous and allogeneic hematopoietic stem cell transplantation. Method: A prospective cohort from September 2013 to February 2019 at a reference service in Latin America with 55 patients. The instruments Quality of Life Questionnaire Core C30 and Functional Assessment Cancer Therapy – Bone Marrow Transplantation were used. For data analysis, Generalized Linear Mixed Model was used. Results: The domains global and overall quality of life presented the lowest scores in the pancytopenia phase: 59.3 and 91.4 in autologous, 55.3 and 90.3 in allogeneic. The mixed method analysis has shown that there was a significant change in scores between the phases throughout the treatment (p< 0.05). Conclusion: Health-related quality of life presented significant changes in the domains between the phases throughout time. Understanding these results enables nursing interventions directed at the domains which were damaged during treatment.