Objective: Assessing the quality of life of adult patients with hematological cancer in the 100 days after transplantation of hematopoietic stem cells and verifying whether the variable graft-versus-host disease (GvHD) is predictive of worse results. Method: An observational correlational and quantitative study with 36 adult participants diagnosed with hematologic cancer who underwent hematopoietic stem cell transplantation from September 2013 to June 2015. Result: The mean age was 37 years, 52.78% were female, and 61.11% were diagnosed with leukemia. Quality of life scores showed a significant impact between pre-transplantation and pre-hospital discharge, and also within the 100 days post-transplantation. The statistical analysis between the scores for the groups with and without GvHD showed a significant difference between the presence of the complication and worse results. Conclusion: Quality of life is altered as a result of hematopoietic stem cells transplantation, especially in patients who have graft-versushost disease. DESCRIPTORS

Objective: to evaluate the quality of life of adult patients with hematologic cancers undergoing hematopoietic stem cell transplantation in the first six months and comparing the transplant modalities.Method: an observational longitudinal study with 55 participants followed during pre-transplantation, after 100 days, and after 180 days in a reference teaching hospital for this treatment in Brazil. Two international instruments were used for the evaluation, both validated and translated into Portuguese (Brazil): The Quality of Life Questionnaire-Core 30 and the Functional Assessment Cancer Therapy-Bone Marrow Transplantation. Results:The results showed that the average age of the participants was 36 years old; 65% (n=36) had a diagnosis of leukemia, and 71% (n=39) underwent allogeneic transplantation. Regarding the Quality of Life Questionnaire-Core 30 instrument, social function and fatigue were significant results, while the functional well-being and treatment outcome evaluation index for the Functional Assessment Cancer Therapy-Bone Marrow Transplantation questionnaire had significant domains between the first and the second stage.Conclusions: despite transplantation being a complex and aggressive treatment, it can be noticed that patients generally perceive their quality of life as satisfactory throughout the therapeutic process. The findings of the study show that a significant portion (69% of patients) recover their quality of life after the first six months of treatment. DESCRIPTORS: QUALIDADE DE VIDA NOS PRIMEIROS SEIS MESES PÓS-TRANSPLANTE DE CÉLULAS-TRONCO HEMATOPOÉTICAS CALIDAD DE VIDA EN LOS PRIMEROS SEIS MESES POST-TRANSPLANTES DE CÉLULAS-TRONCO HEMATOPOÉTICAS RESUMENObjetivo: evaluar la calidad de vida de los pacientes adultos con cáncer hematológico sometidos al transplante de células madre hematopoyéticas en los primeros seis meses y comparar entre las modalidades de trasplante.Método: estudio observacional, longitudinal, con 55 participantes, acompañados en las etapas pre-trasplante, después de 100 días y después de 180 días, en un hospital de enseñanza, referencia en Brasil para este tratamiento. Para la evaluación se utilizaron dos instrumentos internacionales, ambos validados y traducidos a la lengua portuguesa (

Objective: to evaluate the impairment of social and emotional domains of hospitalized patients undergoing hematopoietic stem cells transplantation. Method: an observational, longitudinal study with 25 participants evaluated in the period of pre-transplant, pancytopenia and pre-hospital discharge between September 2013 and September 2014, in a reference hospital for this treatment modality in Brazil. Two international instruments were used, both of which translated and adapted to Portuguese (Brazil): Quality of Life Questionnaire-Core 30 and Functional Assessment Cancer Therapy -Bone Marrow Transplantation. Results: patients have shown a statistically signifi cant decrease in the social domain, and stability of the emotional function along the course of treatment. Conclusion: hematopoietic stem cell transplantation changes the social function of patients with hematologic cancer during hospitalization stage. Thus, patients should receive guidance addressing the social domain in order that it can be less affected.

RESUMO Objetivo: avaliar e identificar os domínios afetados na qualidade de vida, correlacionar com a sobrecarga de cuidado e o desconforto emocional dos cuidadores principais de pacientes adultos com câncer hematológico submetidos ao transplante de células-tronco hematopoéticas. Método: estudo transversal e retrospectivo realizado com 59 cuidadores principais de pacientes submetidos a esta modalidade de tratamento. Foi caracterizado o perfil sociodemográfico e aplicado o questionário de avaliação de qualidade de vida (Medical Outcomes Study 36 - Item Short Form Health Survey), avaliação do desconforto emocional (Self Reporting Questionnaire) e de sobrecarga de cuidado (Zarit Burden Interview). Resultados: os participantes foram predominantes cuidadores principais do sexo feminino, cônjuges e com nível médio de escolaridade. Na avaliação da qualidade de vida foi observada correlação entre a Capacidade Funcional e Dor e entre Aspectos Emocionais e Saúde Mental. O maior escore apresentado pelo desconforto emocional não foi significativo. Em relação à sobrecarga de cuidado a maior frequência se deu entre sobrecarga moderada e moderada a grave. Conclusão: a qualidade de vida de cuidadores principais destes pacientes é prejudicada em diferentes domínios e a sobrecarga de cuidado é significativa; sugere-se que os cuidadores principais do paciente que realiza o transplante de células-tronco hematopoéticas sejam foco também da equipe multiprofissional que assiste o transplantado visando a promover a melhoria da qualidade de vida de ambos.

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