Hematopoietic stem cell transplantation and quality of life during the first year of treatment

Abstract

Objective:to evaluate the quality of life of adult patients with hematological cancer comparing Hematopoietic Stem Cell Transplantation modalities during the first year of treatment. Method:this is an observational and longitudinal research with 55 participants. Data collection was performed in six steps: before transplantation, pancytopenia, before hospital discharge, after 100, 180 and 360 days, in a reference hospital in Brazil for this treatment. The international instruments Quality of Life Questionnaire - Core 30 and Functional Assessment Cancer Therapy - Bone Marrow Transplantation were validated and translated into Portuguese (Brazil). Results:the mean age of participants was 36 years, 65% (n = 36) had leukemia diagnosis and 71% (n = 39) had undergone allogenic transplantation. In the Quality of Life Questionnarie - Core30 instrument, the pain symptom was significant between the first and second stages, and loss of appetite between the third and fourth stages, both in the allogenic group. In the Functional Assessment Cancer Therapy - Bone Marrow Transplantation, the functional well-being domain was significant between the third and fourth stages, also in the allogenic group. Conclusions:although the aggressiveness of treatment affects quality of life, patients consider it satisfactory after the first year. There are few significant differences between autologous and allogenic patients, and both groups have recovered in the course of the process.

Quality of life and changes in the social dimension of hematopoietic stem cell transplants recipients

“…The improvement in the social function and social/family well-being scores, after the end of the hospitalization, is an expected result, since, during hospitalization, the patient remains isolated from family and friends, being only with the team and the companion. Therefore, after discharge, social life tends to be recovered (23) . However, the feeling of social isolation can be prolonged, especially when the patient comes from another area, because even after hospital discharge he/she needs to be followed up daily in the clinic, away from home, routine, and work activities.…”

Impact of educational interventions on psychological distress during allogeneic hematopoietic stem cell transplantation: a randomized study.

“… 23 Kirsch et al (2012) 24 demonstrated the effectiveness of educational/therapeutic interventions, which acted synergistically, on the strengthening of problem-solving during treatment and follow-up. Instead, Marques et al (2012) 25 showed that QoL, measured with QLQ-C30, has lower average scores in the pancytopenia compared to the pre-transplant phase. This is probably due to the critical moments of treatment when complications can occur, endangering patients lives or interfering negatively with their QoL.…”

Cuidados De Enfermagem Ao Paciente Com Doença Enxerto Contra Hospedeiro

“…Curitiba (PR), Brasil. 1 https://orcid.org/ 0000-0003-2863-2547. Email: ingrid_rene@live.com Lattes: http://lattes.cnpq.br/ 5595560607905095 2 https://orcid.org/0000-0001-5157-9698.…”

“…Para que o TCTH aconteça, é necessária preparação, denominada condicionamento, que considera a modalidade de transplante, variando as doses de quimioterápicos, além de considerar a fonte de células do doador (sangue periférico ou medula óssea), o grau de compatibilidade do Human Leukocyte Antigen (HLA), a doença de base, entre outros fatores. [1][2] As complicações relacionadas ao TCTH se devem à histocompatibilidade entre o receptor e o doador, pois quanto maior o grau de incompatibilidade do HLA, maior o risco de rejeição, desenvolvimento tardio ou incompleto do enxerto e da Doença do Enxerto Contra Hospedeiro (DECH). A diferença de sexo entre doador e receptor, o regime do condicionamento e a fonte das células-tronco também são fatores que aumentam a incidência da DECH, que pode ser aguda ou crônica.…”