BACKGROUND AND OBJECTIVES: Inflammation is a defense response of the body to a cellular damage caused by physical, chemical or biological agents, which triggers, among other factors, pain. Although inflammation plays an important role in the protection and regeneration of tissue injury, inflammatory pain results in decreased quality of life. In view of this, the development of safe and less invasive forms for the treatment of inflammatory pain is of great importance. The objective of this study was to evaluate the antihyperalgesic potential of the culture supernatant of keratinocytes and human fibroblasts in an experimental model of inflammatory hyperalgesia. METHODS: Evaluation of carrageenan induced inflammatory hyperalgesia through the use of electronic von Frey in animal models treated with culture supernatant of keratinocytes and fibroblasts. RESULTS: Local administration of naloxone, a nonselective opioid antagonist, in peripheral tissue, has been observed to inhibit the antihyperalgesic effect of the keratinocyte culture supernatant. Fibroblast culture supernatant on days 1 and 3 reverses for 2 hours the carrageenan induced inflammatory hyperalgesia, which is mediated by µ opioid agonist. CONCLUSION: This study indicates that culture supernatant of fibroblasts and keratinocytes is capable of inducing antinociception in inflammatory hyperalgesia, mediated by the release of Evaluation of the keratinocytes or fibroblasts culture supernatant in an inflammatory hyperalgesia model Avaliação do sobrenadante da cultura de queratinócitos ou fibroblastos em modelo de hiperalgesia inflamatória
This study aimed to raise demographic and epidemiological aspects as well as the time until surgery in patients with brachial plexus injury in Minas Gerais, Brazil. Forty-seven patients who underwent surgery were evaluated retrospectively in the period 2010 to 2011. The majority (91.5%) were male, mean age 34.4 years; 56.5% were single or separated; 55.3%, from the countryside of Minas Gerais. With regard to schooling, 47.8% had not completed elementary school level. Most of them (43.5%) had a heavy duty job, including houseworking, agriculture, industry. Traffic accidents were the main cause of the injury (97.9%); and motorcycle accidents accounted for 68.1% of the lesions. The time between the accident and the first view by brachial plexus specialist ranged from 1 month to 30 months. The time between query and specialized surgical treatment ranged from 5 to 18 months, mean 10 months. This study points out the epidemiological characteristics of patients with brachial plexus injuries in Minas Gerais, Brazil. Most of the injuries occurred after motorcycle accident in male patients with unfavorable social and economic conditions. In addition, the surgical timing was far above the recommended, resulting in an unfavorable prognosis for functional recovery. Palavras-chaveResumo O presente estudo objetivou levantar aspectos sociodemográficos e epidemiológicos, bem como o intervalo de tempo até a cirurgia, dos pacientes com trauma do plexo braquial em Belo Horizonte (MG). Quarenta e sete pacientes submetidos à cirurgia foram avaliados retrospectivamente no período de 2010 a 2011. A maioria (91,5%) era do sexo masculino, com média de idade de 34,4 anos; 56,5% eram solteiros ou separados; 55,3%, provenientes do interior do estado de Minas Gerais. No que se refere ao nível de escolaridade, 47,8% não haviam completado o nível de ensino fundamental. A maioria deles (43,5%) exercia atividade braçal (serviços gerais, agricultura, indústria e
Objetivos: Estimar a prevalência de pessoas com estomia de eliminação e caracterizá-las quanto aos aspectos sociodemográficos e clínicos. Método: Estudo transversal descritivo com amostra de 27 pacientes com estomias de eliminação, residentes em uma microrregião do norte de Minas Gerais, que atenderam aos critérios de inclusão. Os dados coletados foram registrados em instrumento utilizado em estudos anteriores e analisados por meio de estatística descritiva. Estudo aprovado pelo Comitê de Ética. Resultados: A prevalência de pessoas com estomia foi de 2,16/10.000, a amostra continha 55,6% de homens, 40,7% eram casados, com média de idade de 59,1 anos, 59,2,% eram alfabetizados e 74,0% tinham baixa renda; 59,3% das estomias decorreram de câncer, sendo mais frequentes os de cólon e reto, 70,4% das estomias eram definitivas e 74,0% eram colostomias. Dermatite foi a principal complicação e 68,2% dos pacientes apresentavam efluente de consistência pastosa e realizavam autocuidado. Conclusão: A prevalência de pessoas com estomia foi semelhante à de outros municípios de Minas Gerais e abaixo do esperado pelas Associações Nacional e Internacional de Ostomizados. A caracterização das pessoas, das estomias e do manejo destas contribuirá para que profissionais de saúde e gestores revisem os protocolos de assistência utilizados na microrregião estudada.
BACKGROUND AND OBJECTIVES: Inflammation is a defense response of the body to a cellular damage caused by physical, chemical or biological agents, which triggers, among other factors, pain. Although inflammation plays an important role in the protection and regeneration of tissue injury, inflammatory pain results in decreased quality of life. In view of this, the development of safe and less invasive forms for the treatment of inflammatory pain is of great importance. The objective of this study was to evaluate the antihyperalgesic potential of the culture supernatant of keratinocytes and human fibroblasts in an experimental model of inflammatory hyperalgesia. METHODS: Evaluation of carrageenan induced inflammatory hyperalgesia through the use of electronic von Frey in animal models treated with culture supernatant of keratinocytes and fibroblasts. RESULTS: Local administration of naloxone, a nonselective opioid antagonist, in peripheral tissue, has been observed to inhibit the antihyperalgesic effect of the keratinocyte culture supernatant. Fibroblast culture supernatant on days 1 and 3 reverses for 2 hours the carrageenan induced inflammatory hyperalgesia, which is mediated by µ opioid agonist. CONCLUSION: This study indicates that culture supernatant of fibroblasts and keratinocytes is capable of inducing antinociception in inflammatory hyperalgesia, mediated by the release of Evaluation of the keratinocytes or fibroblasts culture supernatant in an inflammatory hyperalgesia model Avaliação do sobrenadante da cultura de queratinócitos ou fibroblastos em modelo de hiperalgesia inflamatória
Objective: The objective of our study was to report 5 years of experience in the recognition and management of refractory meralgia paresthetica (MP) in patients who had undergone posterior approach lumbar surgery. Methods: Patients who were in three different hospital centers in Belo Horizonte/MG were selected for an evaluation of the postoperative development of MP. A prospective observational comparative case series study. Level of evidence III. Evaluation of the following parameters: type of support for the patient, surgical time, body mass index. Results: 367 posterior approach lumbar spine surgeries for degenerative pathologies of the lumbar spine were performed. MP was observed in 81 patients (22%). In 65 of those patients (80%), there was complete resolution of the symptoms with conservative management (local measures and medications for neuropathic pain) in less than two months. Twelve patients improved with a corticosteroid depot injection in the inguinal ligament and four patients required a surgical procedure in the third month. Pneumatic support was the least involved in the development of MP, as well as surgical time <1h and body mass index <25. Conclusion: Refractory MP may occur in patients submitted to posterior approach lumbar spine surgeries. Management includes local measures, medications for neuropathic pain, and corticosteroid injection in the inguinal ligament. Decompression surgery is reserved for rare refractory cases. Level of evidence III; Prospective observational study with comparative case series.
Objectives: To estimate the prevalence of people with elimination stoma and to characterize them for sociodemographic and clinical aspects. Method: A descriptive cross-sectional study with a sample of 27 patients with elimination stomas residing in a microregion in the north of Minas Gerais, who met the inclusion criteria. The data collected were recorded in an instrument used in previous studies and analyzed using descriptive statistics. Study approved by the Ethics Committee. Results: The prevalence of people with stoma was 2.16/10.000, the sample contained 55.6% of men, 40.7% were married, mean age 59.1 years, 59.2% were literate and 74.0% had low income; 59.3% of the stomas were cancerous, more frequent colon and rectum tumours, 70.4% of the stomas were definitive, and 74.0% were colostomies. Dermatitis was the main complication and 68.2% of the patients presented effluent of pasty consistency and performed self-care. Conclusion: The prevalence of people with stoma was like that of other municipalities in Minas Gerais and below that expected by the National and International Ostomized Associations. The characterization of the people, of the stomas and the management of these, will contribute for health professionals and managers to review the assistance protocols used in the studied microregion.
Introduction Refractory occipital neuralgia is a difficult medical condition, especially when the patient has already been submitted to occipital nerve neurectomy and radiofrequency rhizotomy. There is no case report of spinal cord stimulation in the C1-C4 cervical segments for this condition. Objective To evaluate if C1-C4 dorsal spinal cord stimulation is effective in a patient with refractory occipital neuralgia who was already submitted to neurectomy and rhizotomy. Methods After obtaining the approval from the Ethics Committee of one of our institutions, a unilateral laminectomy was performed between C3 and C4, and a neurostimulator lead was conducted until the posterior portion of the C1 arc was in full view. Then we performed an intraoperative test to evaluate the correspondence between pain location and stimulation-induced paresthesias. We could not put the subcutaneous lead for such condition because of the scar tissue of the area and the previous neurectomy. Results After one year of follow up, we noticed a dramatic improvement in pain control, as well as medication withdrawal. The score of the visual analogue scale was 9 before the surgery, and it dropped to 2 after 1 year of follow-up. Conclusion Spinal cord stimulation between the C1 and C4 cervical segments can be an option for selected cases of refractory occipital neuralgia, including those patients who have already been submitted to neurectomy or rhizotomy.
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