Disodium cromoglycate (DSCG) was used in a controlled laboratory study of an IgE-mediated, immediate-type, respiratory response in primates. The respiratory response to antigen was partially inhibited by DSCG. Systemic administration of DSCG did not inhibit active cutaneous reactivity to ascaris antigen or reverse passive cutaneous reactivity to anti-human IgE in rhesus monkeys, DSCG did not inhibit the respiratory eosinophil response which occurs after ascaris challenge in a highly reactive monkey. A possible explanation for the dissociation of the cutaneous and respiratory activity of DSCG in primate immediate-type responses may be the existence of more than one population of mast cells. The intravenous administration of DSCG resulted in transient aberrantly conducted premature beats in 3 normal rhesus monkeys.

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Summary The in vivo fate of antigen-antibody complexes differentially labeled with 125I and 131I in the same animal is described. Antibody responses to the antigen portions of these soluble complexes were followed by determination of antigen-binding capacity using horse and bovine albumins labeled with 125I and 131I. The different in vivo handling of complexes of canine, avian and rabbit complexes and the differential antibody response to the antigenic portion of the complex suggest that under certain conditions different cells may mediate antigen recognition and immune response.