The Differential Fate of Soluble Antigen and Antigen-Antibody Complexes in Rabbits and Their Effect on Antibody Response

Abstract

Summary The in vivo fate of antigen-antibody complexes differentially labeled with 125I and 131I in the same animal is described. Antibody responses to the antigen portions of these soluble complexes were followed by determination of antigen-binding capacity using horse and bovine albumins labeled with 125I and 131I. The different in vivo handling of complexes of canine, avian and rabbit complexes and the differential antibody response to the antigenic portion of the complex suggest that under certain conditions different cells may mediate antigen recognition and immune response.