Bronchial Eosinophilia in Rhesus Monkeys with IgE Mediated Respiratory Responses

Patterson, Roy; Talbot, Catharine H.; Booth, Bernard H.

doi:10.1159/000230419

Cited by 7 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…or aerosol DSCG. An eosinophil response occurred in secretions, figure 4, consistent with the results previously described in a larger study of respiratory eosinophil responses in the monkey [9]. There was no evidence of inhibition of the respiratory eosinophilic response to SAA by DSCG.…”

Section: Resultssupporting

confidence: 89%

“…Total number of respiratory challenges with eosinophil counts done [9]. cretions were determined and the experiment repeated following pre treatment with i.v.…”

Section: Resultsmentioning

confidence: 99%

“…Extension of this system led to the development of a reproducible model which can be for study of certain pharmacologic agents [8]. Initial studies showed that the IgE-mediated primate respiratory response was partially inhibited by an antihis tamine, partially reversed by a beta adrenergic stimulating agent and not affected by a beta adrenergic blocking agent under the conditions of the experiments [8], Further studies demonstrated that highly reactive ani mals had a respiratory eosinophilia following aerosol antigen challenge [9]. In the present studies the rhesus model of reaginic allergy in the pri mate was used to evaluate the effect of DSCG delivered intravenously or by aerosol prior to antigen challenge.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Use of IgE Mediated Responses as a Pharmacologic Test System. The Effect of Disodium Cromoglycate in Respiratory and Cutaneous Reactions and on the Electrocardiograms of Rhesus Monkeys

Patterson¹,

Talbot²,

Brandfonbrener³

1971

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

Disodium cromoglycate (DSCG) was used in a controlled laboratory study of an IgE-mediated, immediate-type, respiratory response in primates. The respiratory response to antigen was partially inhibited by DSCG. Systemic administration of DSCG did not inhibit active cutaneous reactivity to ascaris antigen or reverse passive cutaneous reactivity to anti-human IgE in rhesus monkeys, DSCG did not inhibit the respiratory eosinophil response which occurs after ascaris challenge in a highly reactive monkey. A possible explanation for the dissociation of the cutaneous and respiratory activity of DSCG in primate immediate-type responses may be the existence of more than one population of mast cells. The intravenous administration of DSCG resulted in transient aberrantly conducted premature beats in 3 normal rhesus monkeys.

show abstract

Section: Resultssupporting

confidence: 89%

“…Total number of respiratory challenges with eosinophil counts done [9]. cretions were determined and the experiment repeated following pre treatment with i.v.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Use of IgE Mediated Responses as a Pharmacologic Test System. The Effect of Disodium Cromoglycate in Respiratory and Cutaneous Reactions and on the Electrocardiograms of Rhesus Monkeys

Patterson¹,

Talbot²,

Brandfonbrener³

1971

Int Arch Allergy Immunol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Booth/T ai.bot/P atterson Bronchial secretions were obtained before, and at various time intervals after, antigenic challenge by adaptation of the bronchial brush technique [4,6]. The bronchial secretions were smeared on a microscope slide, air dried and stained with Wright stain.…”

Section: G40mentioning

confidence: 99%

“…Bronchial secretions ob tained from certain ascaris sensitive monkeys after a respiratory res ponse was induced by ascaris, revealed a marked increase in eosino phils [4]. The eosinophilia occurred within 30 min of antigen chal lenge.…”

Section: Introductionmentioning

confidence: 96%