Physicians and surgeons pay much attention to evaluating thyroid nodules due to the malignant potential of these growths. Inflammation has a crucial role in the development of cancer. Increase in the mean platelet volume (MPV) has been described in various inflammatory conditions. Since some of thyroid nodules are malignant, we aimed to compare MPV values between patients with malignant and benign thyroid nodules after precise pathologic diagnosis. We retrospectively analyzed hemograms of patients having undergone thyroid surgery for thyroid nodule between January 2013 and January 2015, and compared them to those recorded in healthy subjects. MPV was higher in the malignant thyroid nodule group than in the benign nodule group (9.1±1 fL vs. 7.8±0.8 fL). The difference was statistically significant (p<0.001). Increased MPV should be considered as an assistive diagnostic tool in differentiating malignant and benign thyroid nodules. However, further prospective studies are required to confirm its usefulness in this population.

SUMMARY OBJECTIVE Tumor budding is a parameter that is increasingly understood in colorectal carcinomas. We aimed to investigate the relationship between tumor budding, prognostic factors, and survival METHODS A total of 185 patients who had undergone colorectal surgery were observed. Tumor budding, the tumor budding score, and the relationship between these and prognostic factors, and survival investigated. RESULTS Tumor budding was found in 91 (49.2%) cases. The relationship between the tumor budding score and histological grade, lymphovascular invasion, perineural invasion, pathological lymph node stage, and mortality rates were significant. CONCLUSION In our study, the relationship between tumor budding and survival is very strong. Considering these findings and the literature, the prognostic significance of tumor budding becomes clear and should be stated in pathology reports.

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Our study confirmed that proline has positive effects on wound healing. However, it revealed that systemic administration of proline is more effective than local administration of proline.

Objective: To investigate the value of preoperative blood tests in predicting lymph node metastasis in colon cancer patients undergoing surgery.

Objective: Breast hamartomas are benign breast tumors, which are observed very rarely. We aimed to share our surgical approaches and a comparison of preoperative and postoperative pathology results of patients applying to breast polyclinics. Materials and Methods:Out of 32.000 patients approximately, we reviewed data of 12 patients with the diagnosis of breast hamartoma retrospectively, who had applied to the breast polyclinic between dates of March 2007 and October 2012.Results: All patients were female and their average age was 35 (17-58 years). Four of the hamartomas were detected in the right breast, and eight in the left breast. The average diameter of lesions was 7.3 cm (3-21cm). The diameter in our three cases was above 10 cm, and they were evaluated as giant hamartomas. All our cases underwent a fine needle aspiration biopsy (FNAB) or a core biopsy preoperatively. When the reports of preoperative biopsies performed on patients who had applied due to a palpable mass and the postoperative pathology reports were compared, it was detected that they showed a substantial correlation. Conclusion:Hamartomas are benign tumors of the breast. The rate of preoperative diagnosis is high when physical examination, imaging and histopathology approaches are taken in combination. Although very rare, a surgical excision should be performed due to the malignant change in tumors. Hamartomların dördü sağ memede sekizi sol memede saptandı. Lezyonların ortalama çapı 7,3 cm idi (min-maks; 3-21). Üç olguda lezyon çapı 10 cm üzerinde olup bu olgular dev hamartom olarak değerlendirildi. Olgularımı-zın hepsine preoperatif ince iğne aspirasyon biyopsisi (İİAB) veya kor biyopsi yapıldı. Ele gelen kitle ile başvuran hastalara yapılan preoperatif biyopsi ile postoperatif patoloji raporları karşılaştırıldığında büyük oranda korelasyon gösterdikleri tespit edildi.Sonuç: Hamartomlar memenin iyi huylu tümörleridir. Fizik muayene, gö-rüntüleme ve histopatolojinin birlikte ele alınmasıyla preoperatif tanı konma oranı yüksektir. Çok nadir de olsa malign değişim göstermesi sebebiyle cerrahi eksizyon yapılmalıdır.

Gastric cancer is the third most common cause of death in men and the fifth common cause of death in women worldwide. Currently, available advanced imaging modalities can predict R0 resection in most patients in the perioperative period. The aim of this study is to determine the role of serum CK18, MMP-9, and TIMP1 levels in predicting R0 resection in patients with gastric cancer. Fifty consecutive patients scheduled for curative surgery with gastric adenocancer diagnosis between 2013 and 2015 were included in the study. One milliliter of blood was taken from the patients included in the study to examine CK18, MMP-9, and TIMP1. CK18, MMP-9, and TIMP1 levels were positively correlated with pathological N and the stage (P < 0.05). The CK18, MMP-9, and TIMP1 averages of those with positive clinical lymph nodes and those in clinical stage 3 were found to be higher than the averages of those with negative clinical lymph nodes and those in clinical stage 2 (P < 0.05). Although serum CK18, MMP-9, and TIMP1 preop measurements in patients scheduled for curative surgery due to gastric adenocarcinoma did not help to gain any idea of tumor resectability, we concluded that our study had valuable results in significantly predicting N3 stage.

BACKGROUND: Acute pancreatitis is a disease with high morbidity and mortality, despite all the advances in technology. The overall mortality rate of acute pancreatitis is 10%, whereas the mortality rate in infected necrotizing pancreatitis is approximately 35%. In this study, we aimed to establish acute pancreatitis in rats in order to try out the alpha-tocopherol treatment protocol and to reveal the results biochemically and histopathologically. METHODS:Twenty-four male male Sprague-Dawley rats weighing between 300 and 350 g were used in the study. In Group 1, 80 µg/kg of normal saline was subcutaneously injected into eight rats; in Group 2, 80 µg/kg of cerulein was subcutaneously injected into eight rats; and in Group 3, 80 µg/kg of cerulein was subcutaneously injected into eight rats. In addition, 30 mg/kg of alpha-tocopherol was intraperitoneally injected into eight rats. RESULTS:The mean Schoenberg score, serum amylase, and lipase and Neutrophil Gelatinase-Associated Lipocalin (NGAL) levels were statistically significantly higher in Group 2 than in Group 1. The mean Schoenberg score and serum amylase and lipase levels were statistically significantly lower in Group 3 than in Group 2. CONCLUSION:In this experimental study rat model of cerulein-induced acute pancreatitis, 30 mg/kg of alpha-tocopherol was injected intraperitoneally to examine its effect on pancreatitis. The improvement was observed in the histopathological examination of pancreatic tissues. We think that alpha-tocopherol may have a therapeutic effect on pancreatic tissue.