The Role of Serum CK18, TIMP1, and MMP-9 Levels in Predicting R0 Resection in Patients with Gastric Cancer

Abstract

Gastric cancer is the third most common cause of death in men and the fifth common cause of death in women worldwide. Currently, available advanced imaging modalities can predict R0 resection in most patients in the perioperative period. The aim of this study is to determine the role of serum CK18, MMP-9, and TIMP1 levels in predicting R0 resection in patients with gastric cancer. Fifty consecutive patients scheduled for curative surgery with gastric adenocancer diagnosis between 2013 and 2015 were included in the study. One milliliter of blood was taken from the patients included in the study to examine CK18, MMP-9, and TIMP1. CK18, MMP-9, and TIMP1 levels were positively correlated with pathological N and the stage (P < 0.05). The CK18, MMP-9, and TIMP1 averages of those with positive clinical lymph nodes and those in clinical stage 3 were found to be higher than the averages of those with negative clinical lymph nodes and those in clinical stage 2 (P < 0.05). Although serum CK18, MMP-9, and TIMP1 preop measurements in patients scheduled for curative surgery due to gastric adenocarcinoma did not help to gain any idea of tumor resectability, we concluded that our study had valuable results in significantly predicting N3 stage.

Keratin 18 induces proliferation, migration, and invasion in gastric cancer via the MAPK signalling pathway

“…Zhang et al have reported that silencing KRT18 in colon cancer cells may lead to suppressed proliferation, migration, and invasion capacities of the cells. 10 In line with Zhang's findings, our study 12,13 The underlying mechanism through which KRT18 exhibits its effects on the biological behaviour of GC cells is another aspect emphasized in this study.…”

“…Lahdeniemi et al found that KRT18 regulates colon epithelial cell differentiation by activating the Notch1 signalling pathway 11 . Furthermore, KRT18 was shown to be involved in Fas‐mediated apoptosis in hepatocytes and ovarian cancer cells 12,13 . The underlying mechanism through which KRT18 exhibits its effects on the biological behaviour of GC cells is another aspect emphasized in this study.…”

“…KRT18 is generally expressed in epithelial tissues and continuously expressed in various cancer tissues 10 . Several studies have suggested that increased KRT18 expression in the serum of GC patients indicates poor prognosis 11,12 . However, functional studies of KRT18 in GC tissue and cells have rarely been performed.…”

“…10 Several studies have suggested that increased KRT18 expression in the serum of GC patients indicates poor prognosis. 11,12 However, functional studies of KRT18 in GC tissue and cells have rarely been performed. Therefore, the present study aims to further investigate the roles of KRT18 in GC tissues and cells.…”

KRT18 is correlated with the malignant status and acts as an oncogene in colorectal cancer

“…Besides, Kilic-Baygutalp et al [17] found KRT18 expression was positively associated with clinical stage, tumor stage, and metastasis stage in patients with esophageal cancer. In gastric cancer, high KRT18 expression was suggested to be associated with positive lymph nodes, advanced clinical stage, and chemoresistance [33,34].…”