Globally, gastric cancer (GC) is the second most common malignancy of the digestive tract. 1 GC is the third and fifth most common cause of cancer-related deaths in men and women, respectively, with a relatively high incidence in China and East Asia. 1,2 In 2015, China reported approximately 470 000 new cases of GC and nearly 500 000 associated deaths. 3 Although a comprehensive antitumour pattern based on surgical resection and the combined use of targeted drugs and immunotherapy have improved the prognosis of patients with GC, their 5-year survival and overall survival (OS) rates are far from satisfactory. 4 It is well known that recurrent and distant metastases are the leading causes of death in patients with GC. Therefore, it is necessary to investigate the molecular mechanisms of GC progression and explore novel therapeutic targets. With the development of modern molecular biotechnology, the progression of cancer has been found to be closely associated with the activation of oncogenes and the inactivation of tumour suppressor genes. Keratin 18 (KRT18) is located on chromosome 12q13.13 and encodes the main component of epithelial
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