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BACKGROUND: Acute pancreatitis is a disease with high morbidity and mortality, despite all the advances in technology. The overall mortality rate of acute pancreatitis is 10%, whereas the mortality rate in infected necrotizing pancreatitis is approximately 35%. In this study, we aimed to establish acute pancreatitis in rats in order to try out the alpha-tocopherol treatment protocol and to reveal the results biochemically and histopathologically. METHODS:Twenty-four male male Sprague-Dawley rats weighing between 300 and 350 g were used in the study. In Group 1, 80 µg/kg of normal saline was subcutaneously injected into eight rats; in Group 2, 80 µg/kg of cerulein was subcutaneously injected into eight rats; and in Group 3, 80 µg/kg of cerulein was subcutaneously injected into eight rats. In addition, 30 mg/kg of alpha-tocopherol was intraperitoneally injected into eight rats. RESULTS:The mean Schoenberg score, serum amylase, and lipase and Neutrophil Gelatinase-Associated Lipocalin (NGAL) levels were statistically significantly higher in Group 2 than in Group 1. The mean Schoenberg score and serum amylase and lipase levels were statistically significantly lower in Group 3 than in Group 2. CONCLUSION:In this experimental study rat model of cerulein-induced acute pancreatitis, 30 mg/kg of alpha-tocopherol was injected intraperitoneally to examine its effect on pancreatitis. The improvement was observed in the histopathological examination of pancreatic tissues. We think that alpha-tocopherol may have a therapeutic effect on pancreatic tissue.

OBJECTIVE: The aim of this study was to evaluate antioxidant and cytoprotective effects of iloprost and Vitamin C in a distant organ after abdominal aorta ischemia-reperfusion injury. MATERIAL AND METHODS: Twenty-eight New Zealand rabbits weighing 2,400-2,800 g were used for this study. The rabbits were divided into four equal groups. These groups are control group, sham group, iloprost group, and iloprost + vitamin C group. Suprarenal aorta was occluded with a vascular clamp. Following 30 minutes of ischemia, the vascular clamp was removed. Rabbits in group 3 received 10 ng/kg/min iloprost and those in group 4 received 10 ng/kg/min iloprost and 10 mg/kg vitamin C. At the end of the reperfusion period, the rabbits were sacrifi ced by a high intraperitoneal dose of xylazine + ketamine injection. Myocardial tissue samples were taken for electron microscopic analysis. We evaluated SOD, MDA and catalase in myocardial tissue samples. RESULTS: Iloprost and iloprost + vitamin C groups signifi cantly reduced the oxidative stress markers in tissue samples (p < 0.05) and signifi cantly decreased the myofi brillar injury and mitochondrial morphology changes in the myocardial tissue as shown with electron microscopy (p < 0.05). Myocardial edema was signifi cantly alleviated by iloprost and iloprost + vitamin C administration (p < 0.05). CONCLUSIONS: This study clearly showed that myocardial injury and edema occurred after ischemia-reperfusion of abdominal aorta and that groups administered with iloprost and iloprost + vitamin C showed an attenuation of ischemia-reperfusion injury in distant organs (Tab. 3, Fig. 4, Ref. 30). Text in PDF www.elis.sk.

ÖzetBezoar, yutulan yabancı cisim veya gıdaların sindirilemeyip beslenme yolunda oluşturduğu kitlelerdir. Belirti ve bulgular asemptomatik veya müphem olabilir. Bu yazıda halsizlik ve karın ağrısı şikayeti ile polikliniğe başvurup trikobezoar tanısı konulan 18 yaşında kadın hasta sunuldu. (Ha se ki T›p Bül te ni 2013; 51: 141-3) AnahtarKelimeler:Gastrointestinal sistem, trikobezoar, yabancı cisimler Abs tractBezoars are indigestible conglomerates of foreign bodies or food in the gastrointestinal tract. Signs and symptoms are vague and insidious, and may even be asymptomatic. We present the case of an 18-year-old female patient with trichobezoar who presented to the outpatient clinic with weakness and abdominal pain. (The Me di cal Bul le tin of Ha se ki 2013; 51: 141-3)

ÖzAmaç: İnguinal bölgenin primer onarımlarından sonra nüks herni insidansı %1-20 arasında değişmektedir. Nüks inguinal hernilerde anterior ve posterior yaklaşım yöntemlerinin seçilmesi ve uygulanmasında halen tartışmalar sürmektedir. Kliniğimizde her iki yöntemle opere edilen hastaların sonuçları irdelenmiştir.Yöntemler: Retrospektif olarak yürütülen çalışmaya, 15 yıllık sürede nüks inguinal herni tanısı ile ameliyat edilen 109 hasta dahil edildi. Bunların, 60'ına posterior preperitoneal mesh uygulandı, 49'una ise anterior yaklaşımla Lichtenstein teknikleri uygulandı. Greft olarak prolen polipropilen mesh uygulanan hastaların haftalık, aylık, altı aylık, bir yıllık kontrolleri takip edilerek karşılaştırıldı. İstatistik analizde ki-kare ve Student t-testi kullanıldı. Bulgular:Hastane yatış süre ortalamaları posterior yaklaşımda 1,9 gün, anterior yaklaşımda bir gün idi. Posterior tamir yapılan olguların 57'si erkek üçü kadın olup, ortalama yaş 55,2 (25-80 yıl) idi. Anterior tamir yapılan olguların 46'sı erkek üçü kadın olup, ortalama yaş 56,6 (18-82 yıl) idi. Postoperatif komplikasyon posterior yaklaşımda %8,3, anterior yaklaşımda ise %6 olarak bulundu. Sonuç:İnguinal hernilerin tamirinde anterior prosedürler hızlı yapılması, güvenli olması ve daha az morbidite oranlarından dolayı sık tercih edilse de, nüks gelişmesi halinde aynı alana daha önceki operasyona ikincil enflamasyondan dolayı, ulaşmak zor, zaman alıcı ve kordon elemanlarının yaralanması bakımından tehlike oluşturabilmektedir. Tüm bu risk faktörlerine rağmen yine de anterior yaklaşım uygulanabilmekle beraber daha önce dokunulmamış salim bir alan olan preperitoneal alana mesh yerleştirme tekniği de güvenle uygulanabilir.Anahtar Sözcükler: Nüks inguinal herni, anterior herniorafi, posterior herniorafi Aim: The incidence of recurrent hernia after primary repair of the inguinal hernia ranges from 1% to 20%. There is still controversy over the selection and use of anterior versus posterior approach in the repair of recurrent inguinal hernias. The present study evaluated the outcomes achieved in patients who were operated on using the two methods. Methods:This retrospective study included a total of 109 patients, who underwent an operation due to recurrent inguinal hernia in a period of 15 years. Posterior preperitoneal mesh repair was performed in 60 patients and anterior approach using Lichtenstein technique was used in the remaining 49 patients. Polypropylene mesh graft was used in the repair and the patients were compared after control visits at one week, one month, six moths and one year. The chi-square test and Student's t-test were used in the statistical analysis. Results:The mean length of hospital stay was 1.9 days in the posterior approach group and 1 day in the anterior approach group. Of the patients who underwent repair using posterior approach, 57 were male and three were female with a mean age of 55.2 (range 25-80) years. Of the patients who underwent repair using anterior approach, 46 were male and three were female with a mean age of 56.6 (1...