SUMMARY OBJECTIVE Tumor budding is a parameter that is increasingly understood in colorectal carcinomas. We aimed to investigate the relationship between tumor budding, prognostic factors, and survival METHODS A total of 185 patients who had undergone colorectal surgery were observed. Tumor budding, the tumor budding score, and the relationship between these and prognostic factors, and survival investigated. RESULTS Tumor budding was found in 91 (49.2%) cases. The relationship between the tumor budding score and histological grade, lymphovascular invasion, perineural invasion, pathological lymph node stage, and mortality rates were significant. CONCLUSION In our study, the relationship between tumor budding and survival is very strong. Considering these findings and the literature, the prognostic significance of tumor budding becomes clear and should be stated in pathology reports.

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Helicobacter pylori infection is one of the most prevalent infections in humans. The high prevalence and the association with peptic ulceration and gastric cancer require simple and non-invasive methods for the diagnosis of the infection. Detection of salivary anti-H. pylori IgG antibodies has advantages compared with those on serum. In this study, salivary immunoglobulin G response to H. pylori was evaluated in 100 consecutive dyspeptic patients by enzyme-linked immunosorbent assay (ELISA), in comparison with culture and histopathologic examination of gastric biopsy specimens obtained at endoscopic procedures and assessed the accuracy of salivary diagnosis of the infection. The overall sensitivity and specificity of the test were 87 and 73%, respectively. These results suggest that saliva testing for H. pylori antibodies could be used reliably for screening dyspeptic patients in general practice, especially in children in whom venesection is more difficult.

Metallic prosthetic materials are used in place of bones and joints that have lost their function. Metallosis is a rare complication of the arthroplasty where metallic prostheses are used. It is defined as the infiltration of friction-related metallic debris into periprosthetic bones and soft tissues. Its histology is characterized by widespread lymphoplasmacytic and histiocytic infiltration around metal debris, foreign body giant cells, metal particles, extracellular metal deposits and intracytoplasmic debris in giant cells. Since it can be confused with malignant melanoma due to the presence of pigment as well as, giant cell tumors of the soft tissues and bones, care should be taken in the examination of post-arthroplastic materials. For this reason, we found it worthwhile to present two rare cases of post-arthroplasty metallosis, one developed in the knee joint and the other in the hip joint.

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