Helicobacter pylori infection is one of the most prevalent infections in humans. The high prevalence and the association with peptic ulceration and gastric cancer require simple and non-invasive methods for the diagnosis of the infection. Detection of salivary anti-H. pylori IgG antibodies has advantages compared with those on serum. In this study, salivary immunoglobulin G response to H. pylori was evaluated in 100 consecutive dyspeptic patients by enzyme-linked immunosorbent assay (ELISA), in comparison with culture and histopathologic examination of gastric biopsy specimens obtained at endoscopic procedures and assessed the accuracy of salivary diagnosis of the infection. The overall sensitivity and specificity of the test were 87 and 73%, respectively. These results suggest that saliva testing for H. pylori antibodies could be used reliably for screening dyspeptic patients in general practice, especially in children in whom venesection is more difficult.

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The different types and doses (intermittent or once monthly total dose) of IVI treatments are well tolerated without negative effects on the markers of lipid and protein oxidation and inflammatory indices in chronic HD patients.

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Malignant melanoma of the bladder and renal vein thrombosis are rarely seen in common urologic practice. Here, an interesting case of renal vein thrombosis associated with malignant melanoma involving the bladder is presented.

olymyxin antibiotics are necessarily preferable in the treatment of problematic bacteria such as multi-drug resistance Acinetobacter baumannii, Pseudomonas aeruginosa and carbapenemase-producing enteric microorganism.1 In practice, only polymyxin E (colistin) and polymyxin B are used. There are two major adverse effects related to colistin therapy. Nephrotoxicity is one of the generally observed adverse effects following intravenous treatment of colistin. Neurotoxicity is a less common adverse effect than nephrotoxicity. Neurotoxic side effects are generally mild and reversible after stopping the treatment. The ideal dose for colistin remains uncertain. Colistin loading dose is calculated independently of creatinine clearance (CCr). Our purpose is to discuss this entity. A AB BS ST TR RA AC CT T Colistin is a polymyxin antibiotic that is used for the treatment of multidrug-resistant Gram-negative bacteria. The most important side effects of intravenous colistin is nephrotoxicity and neurotoxicity. Neurotoxicity is seen much less frequently (<%7) than nephrotoxicity. Because of the ideal dose for colistin remains uncertain and loading dose is calculated independently of creatinine clearance in patients with kidney disease its safety is unclear. In this paper we present a case of colistin neurotoxicity in a patient with complaints of weakness, dizziness, visual disturbances, ataxia and peripheral paresthesia 5-6 hours after loading dose who has kidney disease. Colistin treatment was stopped, ascorbic acid was added to the treatment and 2-3 hours after hemodialysis, his neurotoxicity symptoms disappeared.K Ke ey yw wo or rd ds s: : Adverse effects; colistin; polymyxins Ö ÖZ ZE ET T Kolistin, çoklu ilaç dirençli Gram-negatif bakterilerin tedavisinde kullanılan bir polimiksin antibiyotiktir. İntravenöz kolistinin en önemli yan etkileri nefrotoksisite ve nörotoksisitedir. Nö-rotoksisite, nefrotoksisiteye göre daha az (<%7) görülür. Kolistin için ideal doz belirsiz olduğundan ve yükleme dozu böbrek hastalığı olan hastalarda kreatinin klirensinden bağımsız olarak hesaplandığından, güvenliği açık değildir. Bu yazıda böbrek hastalığı olan bir hastaya yükleme dozundan 5-6 saat sonra ortaya çıkan zayıflık, baş dönmesi, görme bozuklukları, ataksi ve periferik paresteziye ilişkin bir kolistin nörotoksik şikayeti sunulmuştur. Hastanın kolistini kesilmiş, tedaviye askorbik asit eklenmiş ve hemodiyalize alınan hastanın 2-3 saat sonra nörotoksisite semptomları kaybolmuştur.A An na ah ht ta ar r K Ke el li im me el le er r: : İstenmeyen etkiler; kolistin; polimiksinler Nilay Şengül SAMANCI,