The Effects of Local and Systemic Administration of Proline on Wound Healing in Rats

Abstract

Our study confirmed that proline has positive effects on wound healing. However, it revealed that systemic administration of proline is more effective than local administration of proline.

Genomic Analysis of 727 Patients with Ehlers-Danlos Syndrome I: Clinical Perspective Relates 23 Genes to a Maternally Influenced Arthritis-Adrenaline Disorder

“…Current guidelines look at patient symptoms to decide if a gene variant: 1) travels more with the disease in question [33] than ostensible health [37], and 2) changes encoded RNA/protein structure sufficiently to warrant qualification as pathogenic [35] and "diagnostic" [38]. Figure 2 modifies this approach by determining: 1) structural disruption (column D) [39] of the DNA-directed protein change in light of that protein's role in disease, here recognizing the key roles of glycine and proline in the collagen triple helix [40]; 2) relevance of a gene and/or gene family to general symptoms of a disease process (columns G, H) rather than to those of a specific disease, here looking at AAD rather than a particular type of EDS; 3) qualifying DNA variants by diagnostic utility for the disease process (column V*DU), recognizing that molecular change, like any laboratory test, must be correlated with family context (column I) and specific disease symptoms (column Fd) before it can suggest a clinical diagnosis (columns IFClin in Figure 2). The approach in Figure 2 honors the long-established role of physicians in translating laboratory results into patient diagnosis and management.…”

“…The approach in Figure 2 honors the long-established role of physicians in translating laboratory results into patient diagnosis and management. Clinical knowledge that proline accounts for 1/3 of the amino acids in fibrillar collagens and the importance of vitamin C-promoted proline hydroxylation for wound healing [40] assigns a variant impact score (Vi in Figure 2) of 5 and likely pathogenic qualification [35] in Table 1.…”

Development of curcumin-loaded liposomes in lysine–collagen hydrogel for surgical wound healing

“…5C, the arrow pointing to the spot marked x shows the completely regenerated epidermal layer, while spot z shows the matured granulation tissue. Spot y shows an abnormal tissue for F3 with deformed epidermal layer and dermis indicating poor wound healing and a lack of regeneration of the epidermal and dermal layers [39].…”

“…In a study by Aydin et al, wounds were inflicted at the back of three groups of Sprague Dawley rats and then each group was treated with proline, topically and intra-peritoneally, while the last group served as the control. Although it was confirmed that proline had some positive effects on wound healing, systemic administration of proline yielded more viable results with regard to enhanced wound healing than topical administration of the compound [39].…”

A proline derivative-enriched methanol fraction from Sideroxylon obtusifolium leaves (MFSOL) stimulates human keratinocyte cells and exerts a healing effect in a burn wound model

“…Proline is only considered essential for the body in situations of burns and other injuries. It plays a crucial role in collagen synthesis and wound healing, mainly by regulating cell differentiation, cell nutrition, growth signaling factors, protein synthesis, and excretion of oxidants from the body ( 31 ). The high demand for proline during wound repair can cause a local proline deficiency.…”