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Key WordsColumn liquid chromatography Mebeverine in dosage forms SummaryA simple and rapid, high performance liquid chromatographic (HPLC) procedure for determination of mebeverine in dosage forms (tablet and liquid) is described. Reversed-Phase chromatography was carried out using a mobile phase containing 0.05 M ammonium acetate buffer and acetonitrile, [(45 %, v/v) pH 5.2] with UV-detection (263 nm). Replicate regression analyses of three standard plots in the concentration range of 0.5-10 meg mL -1 obtained on three different days gave a correlation coefficient > 0.9995 and the coefficient of variation of the slopes < 2.2 %. The assay was precise within day and between days as indicated by ANOVA test. The recoveries from 10 replicate tablets of two commercial mebeverine brands and liquid were in order 99.3,100.5 and 100.1% of the label amount and their coefficient of variations were 1.41, 0.89 and 0.69 %, respectively. The limit of quantitation of mebeverine was 5 ng mL-1.

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