In a series of 64 anal carcinomas in the female 11 had multiple primaries in the ano‐genital tract. Statistical analysis using control series illustrated that this incidence is more than a casual association of these tumors. In 5 patients the second or third primaries were diagnosed within a period of one year or less (synchronous tumors). In 6 patients the time interval for the appearance of other primaries was of more than one year (metachronous tumors). Of the latter group, 5 had previous x‐ray therapy to the area and the enhancing or primary carcinogenic effect of the ionizing radiation cannot be ruled out. It appears evident, however, that primary tumor in the ano‐genital tract in the female deserves careful investigation and follow‐up if cancer patients are to be kept free of disease.
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