Adenocarcinomas of the Anal Canal and Peri-anal Tissues

Cabrera, Aurelio; Tsukada, Yoshiaki; Pickren, John W.

doi:10.1097/00000658-196607000-00017

Cited by 29 publications

(16 citation statements)

References 8 publications

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“…The fistula and its associated abscess can precede the discovery of a carcinoma by up to 10 years and it is claimed that this supports the suggestion that the pre-existence of the fistula and chronic infection eventually lead to malignant degeneration [7, 8]. Three criteria were established to attribute a malignant transformation arising in a fistula-in-ano and include: (1) the fistula must be present for years to exclude the possibility that the malignancy predates the fistula; (2) there should be no synchronous colorectal carcinoma, and (3) the opening of the fistula within the anal canal or rectum should not contain malignancy [5].…”

Section: Discussionmentioning

confidence: 72%

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A Case of Large Mucinous Adenocarcinoma Arising in a Long-Standing Fistula-in-Ano

Erhan¹,

Sakarya²,

Aydede³

et al. 2003

Dig Surg

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Background: Chronic anal fistulas are not rare conditions, however, the development of a carcinoma in a long-standing fistula-in-ano is rare. Methods: The case of a 77-year-old male with a large perianal mucinous adenocarcinoma arising in a long-standing fistula-in-ano is presented. Results: Perianal biopsy revealed mucinous adenocarcinoma. Abdominal CT, double contrast barium examination and flexible sigmoidoscopy revealed no other tumoral lesion in the colon and rectum. Conclusion: The patient underwent abdominoperineal resection including wide tumor excision on the gluteal region. The final reconstruction was performed by bilateral gracilis musculocutaneous flaps. Due to clinical and histopathological evidence it was thought that a curative resection had been performed. To date he is clinically disease free.

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Section: Discussionmentioning

confidence: 72%

“…It is important that a wide margin of perianal tissue including the anal mucosa and ischiorectal spaces with the tumor site should be removed to achieve adequate clearance of tumors invading the surrounding structures [8, 9]. …”

Section: Discussionmentioning

confidence: 99%

A Case of Large Mucinous Adenocarcinoma Arising in a Long-Standing Fistula-in-Ano

Erhan¹,

Sakarya²,

Aydede³

et al. 2003

Dig Surg

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“…Tucker and Hellwig [2] reported 2 cases of adenocarcinoma in the inter mediate zone, discovered on routine examination of hemorrhoidectomy specimens. In the years since, nu merous case reports [8][9][10][11][12][13] have appeared in which the anal ducts or glands were involved as the origin of carci nomas. But the relation of anal carcinoma, anal ducts and anal fistulae is more complex and therefore difficult to assess.…”

Section: Discussionmentioning

confidence: 99%

Minute Adenocarcinoma of Anal Duct Origin

Yamaguchi¹,

Ishida²,

Nishimura³

et al. 1991

Dig Surg

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Primary tumors of anal ducts are considered to be extremely rare. A case of adenocarcinoma of anal duct origin is reported. The pathological presentation of this case was a minute adenocarcinoma located in the anal ducts, which showed a transition from normal anal ducts to carcinoma. This tumor was PKP-negative. There was no fistula in the anorectal region. This fact indicated that the carcinoma cells originated in the anal ducts.

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“…Adenocarcinoma of the anal region is a rare histologic variant of more common tumors in this location; the vast majority of cancers in this region are squamous cell or squamous variants. In most large series of carcinomas of the anal canal, <10% of cases are adenocarcinomas [1][2][3][4]. A recent survey of the American Society of Colon and Rectal Surgeons identified only 52 cases of anal gland adenocarcinoma among patients treated by members of this society [5].…”

Section: Introductionmentioning

confidence: 99%